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Guidelines

MIRAGE

proprotein convertase subtilisin/kexin type 2

Summary

Gene Symbol

PCSK2

Organism

Homo sapiens (human)

External Links

NCBI Gene

5126

PubChem

5126

Alliance of Genome Resources

HGNC:8744

Annotation

Keyword

Alternative splicing
Cleavage on pair of basic residues
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Serine protease
Signal
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P16519	KEX2-like endoprotease 2 Prohormone convertase 2 Proprotein convertase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
proteolysis	IDA	7626024
nervous system development	IEA
peptide hormone processing	IDA	28719828
peptide hormone processing	IBA
protein autoprocessing	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin metabolic process [inference]

insulin processing

hormone metabolic process [inference]

peptide hormone processing

primary metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin metabolic process [inference]

insulin processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin metabolic process [inference]

insulin processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin metabolic process [inference]

insulin processing

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
transport vesicle	IEA
secretory granule	IEA
dendrite	IEA
neuron projection	IBA
perikaryon	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

Displaying **all 3** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	IDA	7626024
serine-type endopeptidase activity	IBA
protein binding	IPI	32814053 7913882

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Proprotein convertase subtilisin/kexin type

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
peptide hormone processing
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 8** entries
InterPro
Galactose-binding-like domain superfamily
Kexin/furin catalytic domain
P domain
Peptidase S8, subtilisin, His-active site
Peptidase S8, subtilisin, Ser-active site
Peptidase S8, subtilisin-related
Peptidase S8/S53 domain superfamily
Peptidase S8/S53 domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	855483	Xenbase:XB-GENE-960013
Danio rerio	100004460		DANRE06459
Monodelphis domestica	100033262		MONDO08876
Oryzias latipes	100049241		ORYLA04972
Equus caballus	100050755		HORSE21140
Ornithorhynchus anatinus	100085012		ORNAN26688
Pongo abelii	100171744		PONAB20460
Ciona intestinalis	100181292		CIOIN14934
Taeniopygia guttata	100223337		TAEGU20233
Oryctolagus cuniculus	100358339		RABIT10249

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025