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Guidelines

MIRAGE

nei like DNA glycosylase 3

Summary

Gene Symbol

NEIL3

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 515343
PubChem: 515343

Annotation

Keyword

Chromosome
DNA repair
DNA-binding
Glycosidase
Lyase
Multifunctional enzyme
Nucleus
Phosphoprotein
Reference proteome
Repeat
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q3MHN7	DNA glycosylase/AP lyase Neil3 Endonuclease VIII-like 3 Nei-like protein 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
base-excision repair	IEA	22301074 30032202
interstrand cross-link repair

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
nucleus
chromosome

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
bubble DNA binding
damaged DNA binding	IEA	22301074
double-stranded DNA binding
single-stranded DNA binding
DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity

lyase activity [inference]

carbon-oxygen lyase activity [inference]

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA-(apurinic or apyrimidinic site) endonuclease activity

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA N-glycosylase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

MCM complex binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

DNA secondary structure binding [inference]

bubble DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

endonuclease 8-like 3

Functional Category

H: Coenzyme transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 13 in total

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Gene Ontology
DNA repair
DNA-(apurinic or apyrimidinic site) endonuclease activity
base-excision repair
catalytic activity
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
damaged DNA binding
endonuclease activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing N-glycosyl compounds
hydrolase activity

Displaying **all 9** entries
InterPro
DNA glycosylase/AP lyase, H2TH DNA-binding
DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site
Formamidopyrimidine-DNA glycosylase, catalytic domain
MutM-like, N-terminal
Small ribosomal subunit protein uS13-like, H2TH
Zinc finger, DNA glycosylase/AP lyase-type
Zinc finger, GRF-type
Zinc finger, RanBP2-type superfamily
Zinc finger, RanBP2-type

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	55247		HUMAN78221
Mus musculus	234258		MOUSE58217
Rattus norvegicus	290729		RATNO11893
Pan troglodytes	471359		PANTR34859
Canis lupus familiaris	475639		CANLF04806
Danio rerio	492463		DANRE07885
Macaca mulatta	699618		MACMU37337
Monodelphis domestica	100017570		MONDO26309
Equus caballus	100060702		HORSE25059
Sus scrofa	100156631		PIGXX09046

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025