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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

Summary

Gene Symbol

PFKFB4

Organism

Homo sapiens (human)

External Links

NCBI Gene

5210

HGNC

8875

KEGG Gene ID

hsa:5210

PubChem

5210

Alliance of Genome Resources

HGNC:8875

Annotation

Keyword

ATP-binding
Alternative splicing
Hydrolase
Kinase
Multifunctional enzyme
Nucleotide-binding
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
B7Z5C3
Q5XLC3
Q66S35
Q16877	6PF-2-K/Fru-2,6-P2ase testis-type isozyme

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
fructose metabolic process	IEA
carbohydrate phosphorylation	IEA
fructose 2,6-bisphosphate metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

phosphorylation [inference]

carbohydrate phosphorylation

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

carbohydrate phosphorylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

carbohydrate phosphorylation

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

carbohydrate derivative metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

phosphorylation [inference]

carbohydrate phosphorylation

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
cytosol	IBA TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

Displaying **all 4** entries
GO Term	Evidence Code	PMID
fructose-2,6-bisphosphate 2-phosphatase activity	IBA
ATP binding	IEA
protein binding	IPI	32296183
6-phosphofructo-2-kinase activity	IBA NAS	10095107

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

carbohydrate kinase activity [inference]

phosphofructokinase activity [inference]

6-phosphofructo-2-kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

phosphofructokinase activity [inference]

6-phosphofructo-2-kinase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

carbohydrate phosphatase activity [inference]

sugar-phosphatase activity [inference]

fructose-2,6-bisphosphate 2-phosphatase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K19030

Name

6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 4 [EC:2.7.1.105 3.1.3.46]

References

16311927

Rhea

H₂O + β-D-fructose 2,6-bisphosphate

phosphate + β-D-fructose 6-phosphate

Enzyme

3.1.3.46

PMID

ATP + β-D-fructose 6-phosphate

H⁺ + ADP + β-D-fructose 2,6-bisphosphate

Enzyme

2.7.1.105

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 35 in total

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DO ID	Disease Name	Source
DOID:10283	prostate cancer	DisGeNET DisGeNET
DOID:10286	prostate carcinoma	DisGeNET DisGeNET
DOID:10534	stomach cancer	DisGeNET DisGeNET
DOID:11054	urinary bladder cancer	DisGeNET DisGeNET DisGeNET
DOID:1612	breast cancer	DisGeNET DisGeNET DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:1793	pancreatic cancer	DisGeNET DisGeNET DisGeNET
DOID:1909	melanoma	DisGeNET
DOID:3008	invasive ductal carcinoma	DisGeNET
DOID:3068	glioblastoma	DisGeNET DisGeNET DisGeNET DisGeNET

Ortholog

Displaying entries **81 - 88** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Athene cunicularia	113484722		ATHCN12966
Propithecus coquereli	105809144		PROCO00217
Saccharomyces cerevisiae S288C	853286	SGD:S000003691
Cyprinus carpio carpio	109092986		CYPCA120165
Nannospalax galili	103750221		NANGA14074
Corvus moneduloides	116449191		CORMO01559
Carlito syrichta	103260622		CARSF19613
Strigops habroptila	115614175		STRHB20501

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024