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PHD finger protein 2

Summary

Gene Symbol

PHF2

Organism

Homo sapiens (human)

External Links

NCBI Gene

5253

PubChem

5253

Alliance of Genome Resources

HGNC:8920

Annotation

Keyword

3D-structure
Acetylation
Activator
Centromere
Chromatin regulator
Chromosome
Dioxygenase
Iron
Isopeptide bond
Kinetochore
Nucleus
Phosphoprotein
Reference proteome
Transcription regulation
Ubl conjugation
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
O75151	GRC5 PHD finger protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
liver development	TAS	21532585
chromatin remodeling	IBA
regulation of transcription by RNA polymerase II	IBA
protein demethylation	IDA	21532585
transcription initiation-coupled chromatin remodeling	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dealkylation [inference]

protein demethylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dealkylation [inference]

protein demethylation

demethylation [inference]

protein demethylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dealkylation [inference]

protein demethylation

macromolecule modification [inference]

protein modification process [inference]

protein dealkylation [inference]

protein demethylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dealkylation [inference]

protein demethylation

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

transcription initiation-coupled chromatin remodeling

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

gland development [inference]

liver development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of heterochromatin formation [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of rDNA heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of heterochromatin formation [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of rDNA heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of heterochromatin formation [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of rDNA heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of chromatin organization [inference]

negative regulation of heterochromatin organization [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of heterochromatin formation [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of rDNA heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of chromatin organization [inference]

negative regulation of heterochromatin organization [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of chromatin organization [inference]

negative regulation of heterochromatin organization [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of chromatin organization [inference]

regulation of heterochromatin organization [inference]

regulation of heterochromatin formation [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of rDNA heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

negative regulation of heterochromatin organization [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

negative regulation of chromatin organization [inference]

negative regulation of heterochromatin organization [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
kinetochore	IDA	20813266
nucleus	TAS	10051327
nucleoplasm	TAS
nucleoplasm	IDA
nucleolus	IDA	20129925

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

supramolecular complex [inference]

kinetochore

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
transcription coregulator activity	IBA
transcription coactivator activity	IDA	21532585
iron ion binding	IDA	21167174
protein binding	IPI	21532585 30021884 35271311
zinc ion binding	IDA	20129925

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

histone H4K20 demethylase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

histone H4K20 demethylase activity

demethylase activity [inference]

protein demethylase activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K9 demethylase activity

histone H4 demethylase activity [inference]

histone H4K20 demethylase activity

catalytic activity, acting on a protein [inference]

protein demethylase activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K9 demethylase activity

histone H4 demethylase activity [inference]

histone H4K20 demethylase activity

histone modifying activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K9 demethylase activity

histone H4 demethylase activity [inference]

histone H4K20 demethylase activity

binding [inference]

protein binding

histone binding [inference]

methylated histone binding

modification-dependent protein binding [inference]

methylation-dependent protein binding [inference]

methylated histone binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

transcription regulator activity [inference]

transcription coregulator activity

transcription coactivator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Lysine-specific demethylase phf2

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
dioxygenase activity
histone demethylase activity
metal ion binding
oxidoreductase activity

Displaying **all 5** entries
InterPro
JmjC domain
Jumonji, helical domain
Zinc finger, FYVE/PHD-type
Zinc finger, PHD-finger
Zinc finger, RING/FYVE/PHD-type

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5253	Xenbase:XB-GENE-6065306
Mus musculus	18676		MOUSE10626
Saccharomyces cerevisiae S288C	22992	SGD:S000000853
Saccharomyces cerevisiae S288C	23133	SGD:S000000853
Saccharomyces cerevisiae S288C	84678	SGD:S000000853
Saccharomyces cerevisiae S288C	225876	SGD:S000000853
Saccharomyces cerevisiae S288C	320595	SGD:S000000853
Canis lupus familiaris	484208		CANLF00514
Danio rerio	503778		DANRE02838
Bos taurus	537728		BOVIN34958

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OrthoDB (Group)

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Acknowledgements