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PHD finger protein 2

Summary

Gene Symbol

PHF2

Organism

Homo sapiens (human)

External Links

NCBI Gene

5253

PubChem

5253

Alliance of Genome Resources

HGNC:8920

JoGo

PHF2

TogoVar

PHF2

Annotation

Keyword

3D-structure
Acetylation
Activator
Centromere
Chromatin regulator
Chromosome
Dioxygenase
Iron
Isopeptide bond
Kinetochore
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Transcription regulation
Ubl conjugation
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
O75151	GRC5 PHD finger protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
liver development	TAS	21532585
chromatin remodeling	IBA
regulation of transcription by RNA polymerase II	IBA
protein demethylation	IDA	21532585
transcription initiation-coupled chromatin remodeling	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dealkylation [inference]

protein demethylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dealkylation [inference]

protein demethylation

demethylation [inference]

protein demethylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dealkylation [inference]

protein demethylation

macromolecule modification [inference]

protein modification process [inference]

protein dealkylation [inference]

protein demethylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dealkylation [inference]

protein demethylation

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

transcription initiation-coupled chromatin remodeling

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

gland development [inference]

liver development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of heterochromatin formation [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of rDNA heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of heterochromatin formation [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of rDNA heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of heterochromatin formation [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of rDNA heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of chromatin organization [inference]

negative regulation of heterochromatin organization [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of heterochromatin formation [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of rDNA heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of chromatin organization [inference]

negative regulation of heterochromatin organization [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of chromatin organization [inference]

negative regulation of heterochromatin organization [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of chromatin organization [inference]

regulation of heterochromatin organization [inference]

regulation of heterochromatin formation [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of rDNA heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

negative regulation of heterochromatin organization [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

negative regulation of chromatin organization [inference]

negative regulation of heterochromatin organization [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
kinetochore	IDA	20813266
nucleus	TAS	10051327
nucleoplasm	TAS
nucleoplasm	IDA
nucleolus	IDA	20129925

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

supramolecular complex [inference]

kinetochore

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
histone demethylase activity	IDA	21167174
histone H3K9 demethylase activity	IDA	21532585
methylated histone binding	IDA	20129925 21167174
histone H4K20 demethylase activity	ISS