phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

Summary
Gene Symbol
  • PIK3CA
Aliases
  • PI3K
Organism
Homo sapiens (human)
NCBI Gene
5290
HGNC
8975
KEGG Gene ID
hsa:5290
PubChem
5290
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Angiogenesis
  • Disease variant
  • Kinase
  • Lipid metabolism
  • Phagocytosis
  • Proto-oncogene
  • Reference proteome
  • Serine/threonine-protein kinase
Proteins
Displaying all 2 entries
UniProt Protein Name
P42336
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
  • Phosphoinositide 3-kinase alpha
  • Phosphoinositide-3-kinase catalytic alpha polypeptide
  • Serine/threonine protein kinase PIK3CA
Q4LE51
Gene Ontology (GO)
GO Hierarchy
GO Hierarchy
Human Protein Atlas
ENSG00000121879

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K00922
Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
References
Disease
Disease Ontology
Displaying entries 1 - 10 of 19 in total
DO ID Disease Name Source
DOID:0060075 estrogen-receptor positive breast cancer
DOID:0060669 cerebral cavernous malformation
DOID:0080199 colorectal carcinoma
DOID:0080351 CLOVES syndrome
DOID:0081001 Cowden syndrome 5
DOID:0110861 autosomal recessive polycystic kidney disease
DOID:0111162 epidermal nevus
DOID:10534 stomach cancer
DOID:1324 lung cancer
DOID:1612 breast cancer
The Human Phenotype Ontology
Displaying entries 251 - 260 of 306 in total
HPO ID HPO Term
HP:0012062 Bone cyst
HP:0012114 Endometrial carcinoma
HP:0012118 Laryngeal carcinoma
HP:0012126 Stomach cancer
HP:0012174 Glioblastoma multiforme
HP:0012246 Oculomotor nerve palsy
HP:0012285 Abnormal hypothalamus physiology
HP:0012377 Hemianopia
HP:0012378 Fatigue
HP:0012505 Enlarged pituitary gland
Displaying entries 1 - 10 of 22 in total
Disease ID Disease Name
OMIM:182000
  • seborrheic keratosis
ORPHA:144
  • Lynch syndrome
OMIM:211980
  • lung cancer
ORPHA:221061
  • famililal cerebral cavernous malformations
OMIM:167000
  • ovarian cancer
ORPHA:168984
  • CLAPO syndrome
OMIM:114500
  • colorectal cancer
OMIM:615108
  • Cowden syndrome 5
OMIM:162900
  • nevus, epidermal
OMIM:612918
  • CLOVES syndrome
PubChem Disease
GHR Health Conditions
MedGen Diseases
OMIM Phenotypes
KEGG Diseases
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP001325
Gene Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: December 9, 2024