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phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

Summary

Gene Symbol

PIK3CB

Organism

Homo sapiens (human)

External Links

NCBI Gene

5291

HGNC

8976

KEGG Gene ID

hsa:5291

PubChem

5291

Alliance of Genome Resources

HGNC:8976

Annotation

Keyword

ATP-binding
Autophagy
Cell adhesion
Cytoplasm
Endocytosis
Kinase
Lipid metabolism
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DER4
P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta Serine/threonine protein kinase PIK3CB

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 40 in total

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GO Term	Evidence Code	PMID
endothelial cell proliferation	IEA
regulation of cell-matrix adhesion	IMP	25139353
response to ischemia	ISS	30496354
sphingosine-1-phosphate receptor signaling pathway	IMP	18558630
intracellular calcium ion homeostasis	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

leukocyte mediated cytotoxicity [inference]

natural killer cell mediated cytotoxicity

lymphocyte mediated immunity [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

immune response [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

autophagy

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cellular catabolic process [inference]

autophagy

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cellular process [inference]

cell activation [inference]

platelet activation

cell killing [inference]

leukocyte mediated cytotoxicity [inference]

natural killer cell mediated cytotoxicity

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

G protein-coupled receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

intracellular signal transduction [inference]

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

cell population proliferation [inference]

epithelial cell proliferation [inference]

endothelial cell proliferation

vesicle-mediated transport [inference]

endocytosis

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cellular catabolic process [inference]

autophagy

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cell motility [inference]

cell migration

cell division [inference]

embryonic cleavage

process utilizing autophagic mechanism [inference]

autophagy

multicellular organismal process [inference]

cell activation [inference]

platelet activation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis [inference]

angiogenesis involved in wound healing

locomotion [inference]

taxis [inference]

chemotaxis

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

response to stimulus [inference]

response to stress [inference]

response to ischemia

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

immune response [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of neutrophil apoptotic process

regulation of neutrophil apoptotic process [inference]

positive regulation of neutrophil apoptotic process

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of nitric oxide biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

regulation of vascular endothelial growth factor signaling pathway [inference]

negative regulation of vascular endothelial growth factor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of hypoxia-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of hypoxia-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

regulation of clathrin-dependent endocytosis

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of nitric oxide biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of myeloid cell apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of leukocyte apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of cellular response to hypoxia [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of cellular response to vascular endothelial growth factor stimulus [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of cellular response to hypoxia [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

regulation of vascular endothelial growth factor signaling pathway [inference]

negative regulation of vascular endothelial growth factor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of hypoxia-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of hypoxia-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of cellular response to vascular endothelial growth factor stimulus [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of cellular response to hypoxia [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of cellular response to hypoxia [inference]

negative regulation of cellular response to hypoxia [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

regulation of cellular response to growth factor stimulus [inference]

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of cellular response to vascular endothelial growth factor stimulus [inference]

negative regulation of vascular endothelial growth factor signaling pathway

regulation of cellular response to vascular endothelial growth factor stimulus [inference]

regulation of vascular endothelial growth factor signaling pathway [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of cellular response to vascular endothelial growth factor stimulus [inference]

negative regulation of vascular endothelial growth factor signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

negative regulation of sprouting angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

negative regulation of sprouting angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

G protein-coupled receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

intracellular signal transduction [inference]

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

regulation of vascular endothelial growth factor signaling pathway [inference]

negative regulation of vascular endothelial growth factor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of hypoxia-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of hypoxia-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of myeloid cell apoptotic process [inference]

regulation of neutrophil apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of myeloid cell apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of apoptotic process [inference]

positive regulation of myeloid cell apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of leukocyte apoptotic process [inference]

positive regulation of neutrophil apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

regulation of leukocyte apoptotic process [inference]

regulation of neutrophil apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of leukocyte apoptotic process [inference]

positive regulation of neutrophil apoptotic process

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of hypoxia-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of myeloid cell apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of leukocyte apoptotic process [inference]

positive regulation of neutrophil apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of myeloid cell apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of leukocyte apoptotic process [inference]

positive regulation of neutrophil apoptotic process

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

negative regulation of cellular response to hypoxia [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

regulation of clathrin-dependent endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

regulation of clathrin-dependent endocytosis

regulation of cellular response to stress [inference]

regulation of cellular response to hypoxia [inference]

negative regulation of cellular response to hypoxia [inference]

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

negative regulation of sprouting angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of sprouting angiogenesis

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
cytosol	TAS
plasma membrane	IBA
phosphatidylinositol 3-kinase complex	IBA
phosphatidylinositol 3-kinase complex, class IA	NAS	20379207
phosphatidylinositol 3-kinase complex, class IA	IPI	20713702 22402981

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

phosphatidylinositol 3-kinase complex

phosphatidylinositol 3-kinase complex, class I [inference]

phosphatidylinositol 3-kinase complex, class IA

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

phosphatidylinositol 3-kinase complex

phosphatidylinositol 3-kinase complex, class I [inference]

phosphatidylinositol 3-kinase complex, class IA

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

midbody

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	19380743 20713702 22402981 25241761 25556234 25814554 26496610 27107012 28514442 32707033 32814053 33961781 35271311
ATP binding	IEA
kinase activity
1-phosphatidylinositol-3-kinase activity	TAS	21035500
1-phosphatidylinositol-3-kinase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity

lipid kinase activity [inference]

phosphatidylinositol kinase activity [inference]

protein kinase activity [inference]

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine kinase activity

phosphatidylinositol kinase activity [inference]

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine kinase activity

binding [inference]

protein binding

insulin receptor substrate binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Phosphatidylinositol

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
kinase activity
phosphatidylinositol-mediated signaling
phosphorylation
transferase activity

Displaying **all 10** entries
InterPro
Armadillo-type fold
C2 domain superfamily
C2 phosphatidylinositol 3-kinase-type domain
Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Phosphatidylinositol 3-/4-kinase, catalytic domain
Phosphatidylinositol 3/4-kinase, conserved site
Phosphatidylinositol kinase
Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
Phosphoinositide 3-kinase, accessory (PIK) domain
Protein kinase-like domain superfamily

KEGG BRITE Database

Orthology

K00922

Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]

References

Rhea

RHEA:21292

ATP + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

H⁺ + ADP + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)

Enzyme

2.7.1.153

PMID

RHEA:17989

ATP

H⁺ + ADP

Enzyme

PMID

RHEA:46608

ATP

H⁺ + ADP

Enzyme

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:2526	prostate adenocarcinoma	Alliance of Genome Resources
DOID:3068	glioblastoma	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001333
Gene Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta

Ortholog

Displaying entries **41 - 50** of **106** in total

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Species	Gene ID	Orthologous MAtrix
Ficedula albicollis	101821801	FICAL11681
Melopsittacus undulatus	101875168	MELUD00686
Chrysemys picta bellii	101940315	CHRPI02407
Ictidomys tridecemlineatus	101970750	ICTTR14719
Chinchilla lanigera	102015651	CHILA20608
Capra hircus	102185042	CAPHI12543
Haplochromis burtoni	102289897	HAPBU11930
Latimeria chalumnae	102359335	LATCH09814
Myotis lucifugus	102441064	MYOLU01787
Pelodiscus sinensis	102461096	PELSI02357

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements