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MIRAGE
pyruvate kinase L/R
Summary
- Gene Symbol
-
- PKLR
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Allosteric enzyme
- Alternative splicing
- Disease variant
- Glycolysis
- Hereditary hemolytic anemia
- Kinase
- Magnesium
- Manganese
- Metal-binding
- Phosphoprotein
- Potassium
- Pyruvate
- Reference proteome
- Proteins
| UniProt | Protein Name |
|---|---|
| P30613 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to hypoxia | ||
| glycolytic process | ||
| glycolytic process | ||
| glycolytic process | ||
| response to nutrient |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound catabolic process [inference]
catabolic process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
aromatic compound catabolic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound catabolic process [inference]
cellular catabolic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
heterocycle catabolic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
organophosphate metabolic process [inference]
organic cyclic compound metabolic process [inference]
organonitrogen compound metabolic process [inference]
organic substance catabolic process [inference]
cellular process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
aromatic compound catabolic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound catabolic process [inference]
cellular catabolic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
heterocycle catabolic process [inference]
response to stimulus [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytoplasm | ||
| cytosol | ||
| extracellular exosome | ||
| pyruvate kinase complex |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| magnesium ion binding | ||
| pyruvate kinase activity | ||
| pyruvate kinase activity | ||
| protein binding | ||
| ATP binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Pyruvate kinase
- Functional Category
-
- C: Energy production and conversion
- G: Carbohydrate transport and metabolism
- K: Transcription
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| catalytic activity |
| kinase activity |
| magnesium ion binding |
| metal ion binding |
| nucleotide binding |
| phosphorylation |
| potassium ion binding |
| pyruvate kinase activity |
| transferase activity |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111077 | congenital nonspherocytic hemolytic anemia 2 | |
| DOID:12365 | malaria | |
| DOID:1926 | Gaucher's disease | |
| DOID:2861 | congenital nonspherocytic hemolytic anemia | |
| DOID:9352 | type 2 diabetes mellitus |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000952 | Jaundice |
| HP:0000980 | Pallor |
| HP:0001081 | Cholelithiasis |
| HP:0001082 | Cholecystitis |
| HP:0001511 | Intrauterine growth retardation |
| HP:0001744 | Splenomegaly |
| HP:0001789 | Hydrops fetalis |
| HP:0001790 | Nonimmune hydrops fetalis |
| Disease ID | Disease Name |
|---|---|
| ORPHA:766 |
|
| OMIM:266200 |
|
| OMIM:102900 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 5313 | Xenbase:XB-GENE-5918041 | ||
| 5315 | SGD:S000005874 | ||
| 18746 | FB:FBgn0267385 | ||
| 18770 | MOUSE38518 | ||
| 24651 | Xenbase:XB-GENE-5918041 | RATNO22779 | |
| 25630 | SGD:S000005874 | ||
| 42620 | Xenbase:XB-GENE-5918041 | ||
| 114551 | DANRE11581 | ||
| 446067 | TAKRU46373 | ||
| 469513 | PANTR22503 |
