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Glycan Structure Repository

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Glycoconjugate Repository

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Glycomics MS raw data Repository

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Glycomics MS Repository for glycan annotations from GlycoWorkbench

LM-GlycoRepo

Repository for lectin-assisted multimodality data

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Other Information

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Tools

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Search Tools

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Guidelines

MIRAGE

pyruvate kinase L/R

Summary

Gene Symbol

PKLR

Organism

Homo sapiens (human)

External Links

NCBI Gene

5313

HGNC

9020

KEGG Gene ID

hsa:5313

PubChem

5313

Alliance of Genome Resources

HGNC:9020

JoGo

PKLR

TogoVar

PKLR

Annotation

Keyword

3D-structure
ATP-binding
Allosteric enzyme
Alternative splicing
Disease variant
Glycolysis
Hereditary hemolytic anemia
Kinase
Magnesium
Manganese
Metal-binding
Phosphoprotein
Potassium
Proteomics identification
Pyruvate
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P30613	Pyruvate kinase 1 Pyruvate kinase isozymes L/R R-type/L-type pyruvate kinase Red cell/liver pyruvate kinase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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2

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GO Term	Evidence Code	PMID
response to hypoxia	IEA
glycolytic process	NAS
glycolytic process	IBA
glycolytic process	IEA
response to nutrient	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

generation of precursor metabolites and energy [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

phosphorus metabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ATP metabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

pyridine nucleotide catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ATP metabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nicotinamide nucleotide metabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

purine nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

pyridine nucleotide catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ATP metabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

pyridine nucleotide catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

catabolic process [inference]

carbohydrate catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process [inference]

canonical glycolysis

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

pyridine nucleotide catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process [inference]

canonical glycolysis

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

pyridine nucleotide catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

purine-containing compound catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

pyridine-containing compound catabolic process [inference]

pyridine nucleotide catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

carbohydrate derivative catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

biosynthetic process [inference]

small molecule biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

pyruvate biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

glucose catabolic process [inference]

canonical glycolysis

hexose catabolic process [inference]

glucose catabolic process [inference]

canonical glycolysis

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process [inference]

canonical glycolysis

carbohydrate catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process [inference]

canonical glycolysis

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

pyridine nucleotide catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ATP metabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

pyridine nucleotide catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ATP metabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nicotinamide nucleotide metabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

purine nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

pyridine nucleotide catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

glucose catabolic process [inference]

canonical glycolysis

hexose catabolic process [inference]

glucose catabolic process [inference]

canonical glycolysis

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process [inference]

canonical glycolysis

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

pyruvate metabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

pyruvate biosynthetic process

monocarboxylic acid biosynthetic process [inference]

pyruvate biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

pyruvate biosynthetic process

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process [inference]

canonical glycolysis

small molecule biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

pyruvate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ATP metabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

pyridine nucleotide catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ATP metabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nicotinamide nucleotide metabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleoside diphosphate metabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

purine nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

pyridine nucleotide catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ATP metabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

purine-containing compound catabolic process [inference]

purine nucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

pyridine-containing compound metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

pyridine-containing compound catabolic process [inference]

pyridine nucleotide catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ADP metabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ATP metabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

carbohydrate derivative catabolic process [inference]

ribonucleotide catabolic process [inference]

purine ribonucleotide catabolic process [inference]

ADP catabolic process [inference]

glycolytic process

glycolytic process through fructose-6-phosphate [inference]

glycolytic process through glucose-6-phosphate [inference]

canonical glycolysis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to epinephrine stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to nutrient levels [inference]

response to nutrient

response to chemical [inference]

response to nutrient

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to metal ion

response to organophosphorus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to epinephrine stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to epinephrine [inference]

cellular response to epinephrine stimulus

response to nitrogen compound [inference]

response to purine-containing compound [inference]

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to ATP

response to peptide hormone [inference]

response to insulin [inference]

cellular response to insulin stimulus

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to epinephrine stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus [inference]

cellular response to insulin stimulus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytoplasm	IBA
cytosol	TAS
extracellular exosome	HDA
pyruvate kinase complex	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

pyruvate kinase complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **6 - 10** of 11 in total

« First

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1

2

3

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GO Term	Evidence Code	PMID
pyruvate kinase activity	IEA
protein binding	IPI
ATP binding
kinase activity
potassium ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

pyruvate kinase activity

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

alkali metal ion binding [inference]

potassium ion binding

monosaccharide binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000143627

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K12406

Name

pyruvate kinase isozymes R/L [EC:2.7.1.40]

References

Rhea

pyruvate + ATP

H⁺ + ADP + phosphoenolpyruvate

Enzyme

2.7.1.40

PMID

pyruvate + UTP

H⁺ + UDP + phosphoenolpyruvate

Enzyme

2.7.1.40

PMID

pyruvate + GTP

H⁺ + GDP + phosphoenolpyruvate

Enzyme

2.7.1.40

PMID

pyruvate + CTP

H⁺ + CDP + phosphoenolpyruvate

Enzyme

2.7.1.40

PMID

pyruvate + dATP

H⁺ + dADP + phosphoenolpyruvate

Enzyme

2.7.1.40

PMID

pyruvate + ITP

H⁺ + IDP + phosphoenolpyruvate

Enzyme

2.7.1.40

PMID

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:12365	malaria	Alliance of Genome Resources
DOID:2861	congenital nonspherocytic hemolytic anemia	Alliance of Genome Resources
DOID:0111077	congenital nonspherocytic hemolytic anemia 2	Alliance of Genome Resources
DOID:1926	Gaucher's disease	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 29 in total

1

2

3

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000952	Jaundice
HP:0000980	Pallor
HP:0001081	Cholelithiasis
HP:0001082	Cholecystitis
HP:0001511	Intrauterine growth retardation
HP:0001744	Splenomegaly
HP:0001789	Hydrops fetalis
HP:0001790	Nonimmune hydrops fetalis

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:102900	pyruvate kinase hyperactivity
OMIM:266200	pyruvate kinase deficiency of red cells
ORPHA:766	pyruvate kinase deficiency of red cells

PubChem Disease

GHR Health Conditions

Pyruvate kinase deficiency

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Pyruvate kinase deficiency

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Saccharomyces cerevisiae S288C	854529	SGD:S000005874
Rattus norvegicus	24651	RGD:3336
Drosophila melanogaster	42620	FB:FBgn0267385

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026