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eukaryotic translation initiation factor 2 alpha kinase 3

Summary

Gene Symbol

EIF2AK3

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 535820
PubChem: 535820

Annotation

Keyword

3D-structure
Endoplasmic reticulum
Glycoprotein
Reference proteome
Signal
Stress response
Translation regulation
Transmembrane helix
Unfolded protein response

Proteins

Displaying 1 entry
UniProt	Protein Name
A5D791

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
ossification
angiogenesis
ER overload response
positive regulation of vascular endothelial growth factor production
endoplasmic reticulum unfolded protein response

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

protein autophosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

protein autophosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

protein autophosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

protein autophosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

protein autophosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

protein autophosphorylation

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

ER overload response

endoplasmic reticulum unfolded protein response

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

protein autophosphorylation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

response to endoplasmic reticulum stress [inference]

cellular response to cold

cellular response to biotic stimulus [inference]

ER overload response

multicellular organismal process [inference]

ossification

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

endocrine pancreas development

response to stimulus [inference]

response to stress [inference]

response to cold [inference]

cellular response to cold

cellular response to stress [inference]

cellular response to starvation [inference]

response to endoplasmic reticulum stress [inference]

cellular response to cold

response to starvation [inference]

cellular response to starvation [inference]

response to amino acid starvation [inference]

cellular response to amino acid starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

response to starvation [inference]

cellular response to starvation [inference]

response to amino acid starvation [inference]

cellular response to amino acid starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

response to biotic stimulus [inference]

cellular response to biotic stimulus [inference]

ER overload response

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to cold [inference]

cellular response to cold

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

response to endoplasmic reticulum stress [inference]

cellular response to cold

cellular response to biotic stimulus [inference]

ER overload response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation in response to stress [inference]

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation in response to stress [inference]

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of amide metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation in response to stress [inference]

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation in response to stress [inference]

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation in response to stress [inference]

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation in response to stress [inference]

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation in response to stress [inference]

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

ER overload response

endoplasmic reticulum unfolded protein response

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation in response to stress [inference]

regulation of translation in response to endoplasmic reticulum stress [inference]

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translational initiation in response to stress [inference]

regulation of translational initiation by eIF2 alpha phosphorylation [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

regulation of translation initiation in response to endoplasmic reticulum stress [inference]

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	IEA	30032202
cytoplasm	IEA	30032202
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
eukaryotic translation initiation factor 2alpha kinase activity	IEA	30032202
protein binding	IEA	22301074
ATP binding	IEA	22301074
protein phosphatase binding
identical protein binding

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

eukaryotic translation initiation factor 2alpha kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

eukaryotic translation initiation factor 2alpha kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

eukaryotic translation initiation factor 2alpha kinase activity

binding [inference]

protein binding

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

eukaryotic translation initiation factor 2 alpha kinase 3

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 8** entries
Gene Ontology
ATP binding
cellular response to chemical stimulus
eukaryotic translation initiation factor 2alpha kinase activity
kinase activity
nucleotide binding
phosphorylation
response to endoplasmic reticulum stress
response to unfolded protein

Displaying **all 6** entries
InterPro
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Quinoprotein alcohol dehydrogenase-like superfamily
Serine/threonine-protein kinase, active site
WD40/YVTN repeat-like-containing domain superfamily

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	9451	HUMAN63739
Mus musculus	13666	MOUSE47763
Rattus norvegicus	29702	RATNO31925
Pan troglodytes	459388	PANTR28143
Canis lupus familiaris	475756	CANLF05142
Danio rerio	559564	DANRE46701
Macaca mulatta	699575	MACMU07435
Monodelphis domestica	100029557	MONDO04845
Equus caballus	100066488	HORSE09403
Taeniopygia guttata	100223479	TAEGU24480

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements