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dual oxidase 1

Summary

Gene Symbol

DUOX1

Organism

Homo sapiens (human)

External Links

NCBI Gene

53905

PubChem

53905

Alliance of Genome Resources

HGNC:3062

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell membrane
FAD
Glycoprotein
Hydrogen peroxide
Metal-binding
NADP
Reference proteome
Repeat
Signal
Thyroid hormones biosynthesis
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NRD9	Large NOX 1 Long NOX 1 NADPH thyroid oxidase 1 Thyroid oxidase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
thyroid hormone generation	TAS
thyroid hormone generation	IEA
defense response	IBA
response to oxidative stress	IEA
cytokine-mediated signaling pathway	IDA	16111680

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

biosynthetic process [inference]

hormone biosynthetic process

cellular biosynthetic process [inference]

hydrogen peroxide biosynthetic process

organic substance biosynthetic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

hormone metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

hormone biosynthetic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular catabolic process [inference]

hydrogen peroxide catabolic process

cellular biosynthetic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

hydrogen peroxide metabolic process [inference]

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

organic substance metabolic process [inference]

hydrogen peroxide metabolic process [inference]

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

organic substance biosynthetic process [inference]

hydrogen peroxide biosynthetic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular catabolic process [inference]

hydrogen peroxide catabolic process

cellular biosynthetic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

hydrogen peroxide metabolic process [inference]

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

cellular detoxification [inference]

cellular oxidant detoxification

developmental process [inference]

anatomical structure development [inference]

cuticle development

response to stimulus [inference]

response to stress [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to organophosphorus [inference]

response to cAMP

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to oxygen-containing compound [inference]

response to cAMP

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility

regulation of cell motility [inference]

positive regulation of cell motility

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility

positive regulation of cellular process [inference]

positive regulation of cell motility

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

positive regulation of wound healing

positive regulation of response to wounding [inference]

positive regulation of wound healing

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell motility

regulation of cell motility [inference]

positive regulation of cell motility

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

hormone biosynthetic process

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	19339556
plasma membrane	TAS
plasma membrane	IDA	19339556
plasma membrane	IBA
cell surface	IGI	22814254

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

NADPH oxidase complex

catalytic complex [inference]

oxidoreductase complex [inference]

NADPH oxidase complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell leading edge

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

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GO Term	Evidence Code	PMID
peroxidase activity	IEA
calcium ion binding	IEA
protein binding	IPI	19339556 33420071
NAD(P)H oxidase H2O2-forming activity	NAS	10806195
NAD(P)H oxidase H2O2-forming activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [inference]

NAD(P)H oxidase H2O2-forming activity

superoxide-generating NAD(P)H oxidase activity

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

antioxidant activity [inference]

peroxidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dual oxidase

Functional Category

P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
calcium ion binding
cellular oxidant detoxification
heme binding
metal ion binding
oxidoreductase activity
response to oxidative stress
superoxide anion generation
superoxide-generating NAD(P)H oxidase activity

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InterPro
Dual oxidase, peroxidase domain
EF-Hand 1, calcium-binding site
EF-hand domain pair
EF-hand domain
FAD-binding 8
FAD-binding domain, ferredoxin reductase-type
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Ferric reductase transmembrane component-like domain
Ferric reductase, NAD binding domain
Haem peroxidase domain superfamily, animal type

Ortholog

Displaying entries **41 - 50** of 69 in total

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Species	Gene ID	Orthologous MAtrix
Pelodiscus sinensis	102461565	PELSI07164
Lepisosteus oculatus	102686607	LEPOC11873
Callorhinchus milii	103188862	CALMI04281
Chlorocebus sabaeus	103245708	CHLSB12687
Carlito syrichta	103264964	CARSF19468
Nannospalax galili	103746936	NANGA09349
Serinus canaria	103816154	SERCA10186
Rhinopithecus roxellana	104653893	RHIRO39400
Macaca nemestrina	105491060	MACNE04030
Mandrillus leucophaeus	105548207	MANLE31536