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alpha 1,4-galactosyltransferase (P1PK blood group)

Summary

Gene Symbol

A4GALT

Aliases

A14GALT
CD77 synthase
Gb3 synthase
Gb3S
P(k)
globotriaosylceramide synthase
lactosylceramide 4-alpha-galactosyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

53947

GGDB ID

gg068

HGNC

18149

mRNA

NM_017436

map

22q11.2-q13.2

Protein

NP_059132

OMIM

607922

KEGG Gene ID

hsa:53947

PubChem

53947

Alliance of Genome Resources

HGNC:18149

Annotation

Keyword

Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid biosynthesis
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9NPC4	Alpha-1,4-N-acetylglucosaminyltransferase Alpha-1,4-galactosyltransferase Alpha4Gal-T1 CD77 synthase Globotriaosylceramide synthase P1/Pk synthase UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase
A0A0S2Z5J1	Alpha-1,4-N-acetylglucosaminyltransferase Alpha-1,4-galactosyltransferase Globotriaosylceramide synthase UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
glycosphingolipid biosynthetic process	NAS TAS	10748143
globoside biosynthetic process	IEA
protein O-linked glycosylation	IBA
plasma membrane organization	IDA	10747952

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

globoside metabolic process [inference]

globoside biosynthetic process

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

globoside metabolic process [inference]

globoside biosynthetic process

glycosphingolipid biosynthetic process

globoside biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

globoside metabolic process [inference]

globoside biosynthetic process

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

globoside metabolic process [inference]

globoside biosynthetic process

glycosphingolipid biosynthetic process

globoside biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

globoside metabolic process [inference]

globoside biosynthetic process

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

globoside metabolic process [inference]

globoside biosynthetic process

glycosphingolipid biosynthetic process

globoside biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

globoside metabolic process [inference]

globoside biosynthetic process

glycosphingolipid biosynthetic process

globoside biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

globoside metabolic process [inference]

globoside biosynthetic process

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

globoside metabolic process [inference]

globoside biosynthetic process

glycosphingolipid biosynthetic process

globoside biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

globoside metabolic process [inference]

globoside biosynthetic process

glycosphingolipid biosynthetic process

globoside biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

globoside metabolic process [inference]

globoside biosynthetic process

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

globoside metabolic process [inference]

globoside biosynthetic process

glycosphingolipid biosynthetic process

globoside biosynthetic process

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

globoside metabolic process [inference]

globoside biosynthetic process

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

globoside biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

plasma membrane organization

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	IDA	10748143
Golgi membrane	NAS TAS	10748143

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
lactosylceramide 4-alpha-galactosyltransferase activity	TAS
toxic substance binding	IEA
acetylglucosaminyltransferase activity	IBA
galactosyltransferase activity	IBA IDA	10747952 10748143

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity

UDP-galactosyltransferase activity [inference]

lactosylceramide 4-alpha-galactosyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity

galactosyltransferase activity

UDP-galactosyltransferase activity [inference]

lactosylceramide 4-alpha-galactosyltransferase activity

binding [inference]

toxic substance binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

mannosyltransferase

Functional Category

C: Energy production and conversion
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Glycosyltransferase, DXD sugar-binding motif
Nucleotide-diphospho-sugar transferases

GlycoGene Database (GGDB)

GGDB ID

gg068

Gene Symbol

A4GALT

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-Gal	G84224TW	Cer	G00059MO	Cer	10747952

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-Gal	G84224TW	Cer	G00059MO	Cer	10747952

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Drosophila melanogaster	NP_608737	NM_134893
Rattus norvegicus	NP_071576	NM_022240
Mus musculus	NP_001004150	NM_001004150

KEGG BRITE Database

Orthology

K01988

Name

lactosylceramide 4-alpha-galactosyltransferase [EC:2.4.1.228]

References

10748143

Reactions

Displaying **all 3** entries
KEGG Reaction	Enzyme	Acceptor	Product
R11375	2.4.1.228	G58896AZ	G12460DL
R11376	2.4.1.228	G00061MO	G33020YH
R05960	2.4.1.228	G84224TW	G00059MO

Rhea

RHEA:11924

a β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + UDP-α-D-galactose

H⁺ + a globoside Gb3Cer (d18:1(4E)) + UDP

Enzyme

2.4.1.228

PMID

Disease

PubChem Disease

MedGen Diseases

Blood group, P1PK system

OMIM Phenotypes

BLOOD GROUP, P1PK SYSTEM

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000442
Gene Name: alpha 1,4-galactosyltransferase

Ortholog

Displaying entries **31 - 40** of 64 in total

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Species	Gene ID	Orthologous MAtrix
Chrysemys picta bellii	101950887	CHRPI35643
Chinchilla lanigera	102012849	CHILA04623
Macaca fascicularis	102134894	MACFA00179
Equus caballus	102150730	HORSE25863
Capra hircus	102190112	CAPHI25844
Latimeria chalumnae	102364135	LATCH08731
Latimeria chalumnae	102367121	LATCH00394
Pelodiscus sinensis	102459009	PELSI15427
Chlorocebus sabaeus	103223426	CHLSB07387
Nannospalax galili	103743444	NANGA07075

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements