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cholinergic receptor, muscarinic 5

Summary

Gene Symbol

Chrm5

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

53949

PubChem

53949

Alliance of Genome Resources

RGD:620027

Annotation

Keyword

Cell membrane
Direct protein sequencing
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P08911
A6HP54

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
gastric acid secretion	IEA
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA
chemical synaptic transmission	IBA
dopamine transport	ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway [inference]

G protein-coupled acetylcholine receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

gastric acid secretion

nervous system process [inference]

transmission of nerve impulse

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

acid secretion [inference]

gastric acid secretion

organic substance transport [inference]

monoamine transport [inference]

catecholamine transport [inference]

dopamine transport

organic hydroxy compound transport [inference]

catecholamine transport [inference]

dopamine transport

nitrogen compound transport [inference]

monoamine transport [inference]

catecholamine transport [inference]

dopamine transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of phosphatidylinositol dephosphorylation

regulation of phospholipid metabolic process [inference]

regulation of phosphatidylinositol dephosphorylation

regulation of macromolecule metabolic process [inference]

regulation of phosphatidylinositol dephosphorylation

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phosphatidylinositol dephosphorylation

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway [inference]

G protein-coupled acetylcholine receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of phosphatidylinositol dephosphorylation

regulation of phospholipid metabolic process [inference]

regulation of phosphatidylinositol dephosphorylation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA
dendrite	IBA
synapse	IBA
postsynaptic membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

Displaying **all 3** entries
GO Term	Evidence Code	PMID
G protein-coupled serotonin receptor activity
G protein-coupled acetylcholine receptor activity	IDA	2540186
G protein-coupled acetylcholine receptor activity	IBA

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled acetylcholine receptor activity

acetylcholine receptor activity [inference]

G protein-coupled acetylcholine receptor activity

neurotransmitter receptor activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

acetylcholine receptor activity [inference]

G protein-coupled acetylcholine receptor activity

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled acetylcholine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

muscarinic acetylcholine receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
G protein-coupled acetylcholine receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

Displaying **all 3** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Muscarinic acetylcholine receptor family

Ortholog

Displaying entries **11 - 20** of 94 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	25229	FB:FBgn0000037
Xenopus tropicalis	37892	Xenbase:XB-GENE-986590
Xenopus tropicalis	53949	Xenbase:XB-GENE-986590
Drosophila melanogaster	81645	FB:FBgn0000037
Xenopus tropicalis	179962	Xenbase:XB-GENE-986590
Mus musculus	213788	Xenbase:XB-GENE-986590	MOUSE34975
Drosophila melanogaster	243764	FB:FBgn0000037
Canis lupus familiaris	487472		CANLF12353
Pan troglodytes	503515		PANTR09875
Danio rerio	553978		DANRE13225