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Guidelines

MIRAGE

DNA polymerase alpha 1, catalytic subunit

Summary

Gene Symbol

POLA1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5422

PubChem

5422

Alliance of Genome Resources

HGNC:9173

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
DNA replication
DNA-binding
DNA-directed DNA polymerase
Direct protein sequencing
Disease variant
Dwarfism
Host-virus interaction
Intellectual disability
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6NMQ1
P09884	DNA polymerase alpha catalytic subunit p180

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **16 - 16** of 16 in total

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GO Term	Evidence Code	PMID
DNA synthesis involved in UV-damage excision repair	IMP	1730053

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

cellular process [inference]

cell cycle process [inference]

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

mitotic cell cycle process [inference]

mitotic DNA replication initiation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA replication, synthesis of RNA primer

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

DNA synthesis involved in UV-damage excision repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

nucleotide-excision repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of type I interferon production

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of type I interferon production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of type I interferon production

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of type I interferon production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of type I interferon production

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
chromatin	IDA	9815285
nucleus	IDA	16762037 4084590
nuclear envelope	IDA	9518481
nucleoplasm	TAS
nucleoplasm	IDA	7045121

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

chromatin

nuclear protein-containing complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

alpha DNA polymerase:primase complex

intracellular protein-containing complex [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

alpha DNA polymerase:primase complex

DNA polymerase complex [inference]

alpha DNA polymerase:primase complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

alpha DNA polymerase:primase complex

DNA polymerase complex [inference]

alpha DNA polymerase:primase complex

cellular anatomical entity [inference]

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
nucleotide binding	IDA	3139084
DNA binding	IDA	16762037
chromatin binding	IDA	16762037
chromatin binding	IBA
DNA replication origin binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

DNA replication origin binding

single-stranded DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

DNA replication origin binding

nucleoside phosphate binding [inference]

nucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dna polymerase

Functional Category

L: Replication, recombination and repair
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 10** entries
Gene Ontology
DNA biosynthetic process
DNA replication origin binding
chromatin binding
lagging strand elongation
leading strand elongation
metal ion binding
mitotic DNA replication initiation
nucleotide binding
nucleotidyltransferase activity
transferase activity

Displaying entries **11 - 13** of 13 in total

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InterPro
Ribonuclease H superfamily
Ribonuclease H-like superfamily
Zinc finger, DNA-directed DNA polymerase, family B, alpha

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111834	X-linked reticulate pigmentary disorder	Alliance of Genome Resources
DOID:0111840	Van Esch-O'Driscoll syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5422	Xenbase:XB-GENE-1000548
Mus musculus	18968		MOUSE66250
Rattus norvegicus	85241		RATNO45057
Danio rerio	317740		DANRE25491
Bos taurus	534848		BOVIN37312
Macaca mulatta	699763		MACMU47028
Xenopus tropicalis	855621	Xenbase:XB-GENE-1000548
Monodelphis domestica	100011328		MONDO20860
Equus caballus	100052225		HORSE44475
Taeniopygia guttata	100227956		TAEGU11882

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Last updated: December 8, 2025