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C-X-C motif chemokine receptor 1

Summary

Gene Symbol

Cxcr1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

54258

PubChem

54258

Alliance of Genome Resources

RGD:2905

Annotation

Keyword

Cell membrane
Chemotaxis
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P70612	High affinity interleukin-8 receptor A
A6JVS8	High affinity interleukin-8 receptor A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
receptor internalization	ISO
calcium-mediated signaling	IBA
cell surface receptor signaling pathway	ISO
neutrophil chemotaxis	IBA
chemokine-mediated signaling pathway	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

response to stimulus [inference]

immune response

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying 1 entry
GO Term	Evidence Code	PMID
external side of plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
interleukin-8 receptor activity	ISO
interleukin-8 binding	ISO
C-C chemokine receptor activity	IBA
C-C chemokine binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytokine binding [inference]

chemokine binding [inference]

C-C chemokine binding

C-X-C chemokine binding [inference]

interleukin-8 binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

interleukin-8 receptor activity

G protein-coupled receptor activity [inference]

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

interleukin-8 receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

interleukin-8 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

C-X-C chemokine receptor type 1

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism

Displaying **all 10** entries
Gene Ontology
C-C chemokine binding
C-C chemokine receptor activity
C-X-C chemokine receptor activity
calcium-mediated signaling
chemokine-mediated signaling pathway
chemotaxis
immune response
interleukin-8 binding
neutrophil chemotaxis
positive regulation of cytosolic calcium ion concentration

Displaying **all 3** entries
InterPro
CXC chemokine receptor 1/2
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0080784	urinary tract infection	Alliance of Genome Resources
DOID:11400	pyelonephritis	Alliance of Genome Resources
DOID:2920	membranoproliferative glomerulonephritis	Alliance of Genome Resources
DOID:526	human immunodeficiency virus infectious disease	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources

Ortholog

Displaying entries **81 - 90** of 90 in total

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Species	Gene ID	OrthoDB
Perognathus longimembris pacificus	125350836	214514_0:0014c4
Myodes glareolus	125416300	447135_0:00351f
Microtus fortis	126489478	100897_0:00428b
Acomys russatus	127196169	60746_0:001f09
Phodopus roborovskii	127226278	109678_0:00275a
Apodemus sylvaticus	127691887	10129_0:002e9a
Peromyscus californicus insignis	128118023	564181_0:00220b
Psammomys obesus	129683668	48139_1:0028fd
Chionomys nivalis	130870047	269649_0:0006be
Peromyscus eremicus	131923171	42410_0:003b2a

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements