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RNA polymerase II subunit B

Summary

Gene Symbol

POLR2B

Organism

Homo sapiens (human)

External Links

NCBI Gene

5431

PubChem

5431

Alliance of Genome Resources

HGNC:9188

Annotation

Keyword

3D-structure
DNA-directed RNA polymerase
Hydrolase
Magnesium
Methylation
Nucleotidyltransferase
Nucleus
Phosphoprotein
Proteomics identification
RNA-directed RNA polymerase
Reference proteome
Zinc-finger

Proteins

Displaying **all 4** entries
UniProt	Protein Name
B4DH29
C9J2Y9
P30876	3'-5' exoribonuclease DNA-directed RNA polymerase II 140 kDa polypeptide DNA-directed RNA polymerase II subunit B RNA polymerase II subunit 2 RNA polymerase II subunit B2 RNA-directed RNA polymerase II subunit RPB2
B4DHJ3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
transcription by RNA polymerase IV	IEA
transcription by RNA polymerase V	IEA
RNA-templated transcription	IEA
transcription, RNA-templated	IEA
transcription by RNA polymerase I	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
chromosome, telomeric region	IDA	24270157
nucleus	IDA	9852112
nucleoplasm	TAS
nucleoplasm	IDA
RNA polymerase II, core complex	IDA	9852112

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

RNA polymerase II, core complex

intracellular protein-containing complex [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

RNA polymerase II, core complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

RNA polymerase II, core complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
DNA binding	IEA
chromatin binding	IEA
RNA binding	HDA	22658674 22681889
DNA-directed 5'-3' RNA polymerase activity	ISS
DNA-directed 5'-3' RNA polymerase activity	IDA	23748380 9852112

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

RNA polymerase activity [inference]

5'-3' RNA polymerase activity [inference]

hydrolase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA polymerase activity [inference]

5'-3' RNA polymerase activity [inference]

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleoside binding [inference]

ribonucleoside binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleoside binding [inference]

ribonucleoside binding

nucleic acid binding [inference]

carbohydrate derivative binding [inference]

nucleoside binding [inference]

ribonucleoside binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dna-directed rna polymerase i

Functional Category

H: Coenzyme transport and metabolism
J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
metal ion binding
nucleotidyltransferase activity
ribonucleoside binding
transferase activity

Displaying entries **1 - 10** of 12 in total

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InterPro
DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
DNA-directed RNA polymerase, subunit 2
RNA polymerase Rpb2, OB-fold
RNA polymerase Rpb2, domain 2 superfamily
RNA polymerase Rpb2, domain 2
RNA polymerase Rpb2, domain 3
RNA polymerase Rpb2, domain 4
RNA polymerase Rpb2, domain 5
RNA polymerase Rpb2, domain 7

Ortholog

Displaying entries **81 - 85** of 85 in total

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Species	Gene ID	Orthologous MAtrix
Corvus moneduloides	116444369	CORMO21221
Chelonoidis abingdonii	116815255	CHEAB20929
Rhinolophus ferrumequinum	117022006	RHIFE18997
Balaenoptera musculus	118895589	BALMU28085
Panthera leo	122218198	PANLE27111

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