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abhydrolase domain containing 2

Summary

Gene Symbol

Abhd2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

54608

PubChem

54608

Alliance of Genome Resources

MGI:1914344

Annotation

Keyword

Cell membrane
Cytoplasmic vesicle
Glycoprotein
Lipid degradation
Reference proteome
Serine esterase
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9QXM0	2-arachidonoylglycerol hydrolase Abhydrolase domain-containing protein 2 Acetylesterase Lung alpha/beta hydrolase 2 Triacylglycerol lipase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
acrosome reaction	IMP	26989199
response to wounding	IMP	15721306
smooth muscle cell migration	IMP	15721306
negative regulation of smooth muscle cell migration	IMP	15721306
intracellular steroid hormone receptor signaling pathway	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

medium-chain fatty acid metabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

medium-chain fatty acid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

acylglycerol catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

medium-chain fatty acid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

acylglycerol catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

medium-chain fatty acid metabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

medium-chain fatty acid metabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

medium-chain fatty acid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

acylglycerol catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

cellular process [inference]

signal transduction [inference]

hormone-mediated signaling pathway [inference]

steroid hormone mediated signaling pathway

intracellular steroid hormone receptor signaling pathway

intracellular receptor signaling pathway [inference]

intracellular steroid hormone receptor signaling pathway

cellular process involved in reproduction in multicellular organism [inference]

sperm capacitation

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

medium-chain fatty acid metabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid biosynthetic process [inference]

medium-chain fatty acid biosynthetic process

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

medium-chain fatty acid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

acylglycerol catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

medium-chain fatty acid catabolic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

acylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process

cellular developmental process [inference]

cell maturation [inference]

sperm capacitation

cell motility [inference]

cell migration [inference]

muscle cell migration [inference]

smooth muscle cell migration

reproductive process [inference]

developmental process involved in reproduction [inference]

sperm capacitation

acrosome reaction

cellular process involved in reproduction in multicellular organism [inference]

sperm capacitation

developmental process [inference]

developmental process involved in reproduction [inference]

sperm capacitation

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

sperm capacitation

cellular developmental process [inference]

cell maturation [inference]

sperm capacitation

response to stimulus [inference]

response to stress [inference]

response to wounding

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to progesterone

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to progesterone

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to progesterone

response to lipid [inference]

response to steroid hormone [inference]

response to progesterone

response to ketone [inference]

response to progesterone

response to oxygen-containing compound [inference]

response to ketone [inference]

response to progesterone

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

regulation of cellular process [inference]

signal transduction [inference]

hormone-mediated signaling pathway [inference]

steroid hormone mediated signaling pathway

intracellular steroid hormone receptor signaling pathway

intracellular receptor signaling pathway [inference]

intracellular steroid hormone receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
acrosomal vesicle	IDA	26989199
acrosomal membrane	IEA
sperm flagellum	ISO
sperm flagellum	IBA
sperm flagellum	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane [inference]

sperm plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

acrosomal membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

acrosomal membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium [inference]

9+2 motile cilium [inference]

sperm flagellum

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium [inference]

9+2 motile cilium [inference]

sperm flagellum

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
nuclear steroid receptor activity	ISS
nuclear steroid receptor activity	ISO
triglyceride lipase activity	IEA
acetylesterase activity	ISS
acetylesterase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

carboxylic ester hydrolase activity [inference]

short-chain carboxylesterase activity [inference]

acetylesterase activity

acylglycerol lipase activity

binding [inference]

hormone binding

molecular transducer activity [inference]

signaling receptor activity [inference]

nuclear steroid receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

abhydrolase domain-containing protein 2

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
acetylesterase activity
acylglycerol catabolic process
acylglycerol lipase activity
medium-chain fatty acid biosynthetic process
medium-chain fatty acid catabolic process
sperm capacitation
steroid hormone mediated signaling pathway

Displaying **all 3** entries
InterPro
AB hydrolase 4 family
Alpha/Beta hydrolase fold
Alpha/beta hydrolase fold-1

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	11057	Xenbase:XB-GENE-1010610	HUMAN24937
Xenopus tropicalis	54608	Xenbase:XB-GENE-1010610
Rattus norvegicus	293050		RATNO18220
Danio rerio	393888	Xenbase:XB-GENE-1010610	DANRE41693
Pan troglodytes	467753		PANTR11106
Canis lupus familiaris	479037		CANLF12046
Bos taurus	508717		BOVIN16381
Danio rerio	559290	Xenbase:XB-GENE-1010610	DANRE27897
Macaca mulatta	699258		MACMU41904
Monodelphis domestica	100013292		MONDO05320

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements