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Guidelines

MIRAGE

CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase

Summary

Gene Symbol

CDKAL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

54901

PubChem

54901

Alliance of Genome Resources

HGNC:21050

JoGo

CDKAL1

TogoVar

CDKAL1

Annotation

Keyword

4Fe-4S
Alternative splicing
Diabetes mellitus
Endoplasmic reticulum
Phosphoprotein
Proteomics identification
Reference proteome
S-adenosyl-L-methionine
Transferase
Transmembrane helix
tRNA processing

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5VV42	CDK5 regulatory subunit-associated protein 1-like 1 tRNA-t(6)A37 methylthiotransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
biological_process	ND
tRNA methylthiolation	IBA
maintenance of translational fidelity	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

macromolecule modification [inference]

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

maintenance of translational fidelity

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

RNA modification [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylthiolation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA
endoplasmic reticulum membrane	TAS
rough endoplasmic reticulum	IEA
membrane	HDA	19946888

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

rough endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

rough endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25416956 32814053
N6-threonylcarbomyladenosine methylthiotransferase activity	IBA
metal ion binding	IEA
4 iron, 4 sulfur cluster binding	IEA
tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

alkylthioltransferase activity [inference]

methylthiotransferase activity [inference]

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

4 iron, 4 sulfur cluster binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
4 iron, 4 sulfur cluster binding
catalytic activity
iron-sulfur cluster binding
metal ion binding
methylthiotransferase activity
tRNA methylthiolation
transferase activity

Displaying **all 8** entries
InterPro
Elp3/MiaA/NifB-like, radical SAM core domain
Methylthiotransferase, N-terminal domain superfamily
Methylthiotransferase, N-terminal
Methylthiotransferase, conserved site
Methylthiotransferase
Radical SAM, alpha/beta horseshoe
Radical SAM
TRAM domain

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:11714	gestational diabetes	Alliance of Genome Resources
DOID:8947	diabetic retinopathy	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025