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Threonylcarbamoyladenosine tRNA methylthiotransferase
Summary
- UniProt ID
- Q5VV42
- Gene Symbol
-
- CDKAL1
- Gene ID
- 54901
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 4Fe-4S
- Alternative splicing
- Diabetes mellitus
- Endoplasmic reticulum
- Phosphoprotein
- Reference proteome
- S-adenosyl-L-methionine
- Transferase
- Transmembrane helix
- tRNA processing
- Gene Ontology (GO)
| GO Term |
|---|
| membrane |
| endoplasmic reticulum |
| endoplasmic reticulum membrane |
| rough endoplasmic reticulum |
| GO Term |
|---|
| tRNA methylthiolation |
| maintenance of translational fidelity |
Sequence
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSHTSAASQCDSASSRMVLPMPRLHQDCALRMSVGLALLGLLFAFFVKVYN
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 108 |
|
|||
| 400 |
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| tRNA modification in the nucleus and cytosol | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:11714 | gestational diabetes | |
| DOID:8947 | diabetic retinopathy | |
| DOID:9351 | diabetes mellitus | |
| DOID:9352 | type 2 diabetes mellitus |
