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1-acylglycerol-3-phosphate O-acyltransferase 5

Summary

Gene Symbol

AGPAT5

Aliases

1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
FLJ11210
LPAAT-e
LPAAT-epsilon
LPLAT5
lysophosphatidic acid acyltransferase, epsilon
lysophospholipid acyltransferase 5

Organism

Homo sapiens (human)

External Links

NCBI Gene

55326

HGNC

20886

KEGG Gene ID

hsa:55326

PubChem

55326

Alliance of Genome Resources

HGNC:20886

Annotation

Keyword

Acyltransferase
Endoplasmic reticulum
Mitochondrion
Nucleus
Phospholipid biosynthesis
Phospholipid metabolism
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9NUQ2	1-acylglycerol-3-phosphate O-acyltransferase 5 Lysophosphatidic acid acyltransferase epsilon
A0A024R640

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
CDP-diacylglycerol biosynthetic process	IEA
hematopoietic progenitor cell differentiation	IEA
phospholipid biosynthetic process		15367102
phosphatidylinositol acyl-chain remodeling	IBA
acylglycerol metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nuclear envelope	IDA	21173190
endoplasmic reticulum	IBA
endoplasmic reticulum membrane	IDA TAS	21173190
endomembrane system	IBA
mitochondrial outer membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

endomembrane system

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

endoplasmic reticulum membrane

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
1-acylglycerol-3-phosphate O-acyltransferase activity	IDA NAS TAS	15367102 21173190
acyltransferase activity	IBA
protein binding	IPI	25416956 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity [inference]

acylglycerol O-acyltransferase activity [inference]

1-acylglycerol-3-phosphate O-acyltransferase activity

lysophospholipid acyltransferase activity [inference]

lysophosphatidic acid acyltransferase activity [inference]

1-acylglycerol-3-phosphate O-acyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K19007

Name

lysophosphatidiate acyltransferase [EC:2.3.1.51]

References

21173190

Rhea

RHEA:19709

a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA

CoA + a 1,2-diacyl-sn-glycero-3-phosphate

Enzyme

2.3.1.51

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001764
Gene Name: 1-acylglycerol-3-phosphate O-acyltransferase 5

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	185044	WB:WBGene00017888
Ciona intestinalis	100177487		CIOIN04692
Callorhinchus milii	103178996		CALMI16852
Latimeria chalumnae	102358621		LATCH07375
Danio rerio	767778	ZFIN:ZDB-GENE-060929-914	DANRE05142
Astyanax mexicanus	103034858		ASTMX02512
Ictalurus punctatus	108263135		ICTPU27357
Electrophorus electricus	113585784		ELEEL06260
Salmo salar	106589814		SALSA119012
Salmo salar	106612554		SALSA11035

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements