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1-acylglycerol-3-phosphate O-acyltransferase 5

Summary

Gene Symbol

AGPAT5

Aliases

1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
FLJ11210
LPAAT-e
LPAAT-epsilon
LPLAT5
lysophosphatidic acid acyltransferase, epsilon
lysophospholipid acyltransferase 5

Organism

Homo sapiens (human)

External Links

NCBI Gene

55326

HGNC

20886

KEGG Gene ID

hsa:55326

PubChem

55326

Alliance of Genome Resources

HGNC:20886

Annotation

Keyword

Acyltransferase
Endoplasmic reticulum
Mitochondrion
Nucleus
Phospholipid biosynthesis
Phospholipid metabolism
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9NUQ2	1-acylglycerol-3-phosphate O-acyltransferase 5 Lysophosphatidic acid acyltransferase epsilon
A0A024R640

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
hematopoietic progenitor cell differentiation	IEA
acylglycerol metabolic process	IEA
phosphatidic acid biosynthetic process	TAS
phospholipid biosynthetic process	NAS	15367102
CDP-diacylglycerol biosynthetic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process

glycerophospholipid metabolic process [inference]

CDP-diacylglycerol metabolic process [inference]

CDP-diacylglycerol biosynthetic process

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol acyl-chain remodeling

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
mitochondrial outer membrane	TAS
endoplasmic reticulum	IBA
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IDA	21173190
endomembrane system	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

endomembrane system

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

endoplasmic reticulum membrane

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
1-acylglycerol-3-phosphate O-acyltransferase activity	NAS	15367102
1-acylglycerol-3-phosphate O-acyltransferase activity	TAS
1-acylglycerol-3-phosphate O-acyltransferase activity	IDA	21173190
protein binding	IPI	25416956 32296183
acyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity [inference]

acylglycerol O-acyltransferase activity [inference]

1-acylglycerol-3-phosphate O-acyltransferase activity

lysophospholipid acyltransferase activity [inference]

lysophosphatidic acid acyltransferase activity [inference]

1-acylglycerol-3-phosphate O-acyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

1-acyl-sn-glycerol-3-phosphate acyltransferase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying 1 entry
Gene Ontology
transferase activity

Displaying **all 2** entries
InterPro
Acyltransferase, C-terminal domain
Phospholipid/glycerol acyltransferase

KEGG BRITE Database

Orthology

K19007

Name

lysophosphatidiate acyltransferase [EC:2.3.1.51]

References

21173190

Rhea

RHEA:19709

a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA

CoA + a 1,2-diacyl-sn-glycero-3-phosphate

Enzyme

2.3.1.51

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001764
Gene Name: 1-acylglycerol-3-phosphate O-acyltransferase 5

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	52123		MOUSE58262
Xenopus tropicalis	55326	Xenbase:XB-GENE-977228
Rattus norvegicus	306582		RATNO10662
Macaca mulatta	716847		MACMU43115
Danio rerio	767778		DANRE05142
Monodelphis domestica	100032605		MONDO03834
Equus caballus	100063996		HORSE25125
Ornithorhynchus anatinus	100075037		ORNAN27762
Pongo abelii	100171477		PONAB34473
Ciona intestinalis	100177487		CIOIN04692

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements