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myo-inositol oxygenase

Summary

Gene Symbol

MIOX

Aliases

kidney-specific protein 32

Organism

Homo sapiens (human)

External Links

NCBI Gene

55586

HGNC

14522

KEGG Gene ID

hsa:55586

PubChem

55586

Alliance of Genome Resources

HGNC:14522

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Iron
Metal-binding
Oxidoreductase
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UGB7	Aldehyde reductase-like 6 Kidney-specific protein 32 Myo-inositol oxygenase Renal-specific oxidoreductase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
inositol catabolic process	IBA IDA ISS	18364358

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol catabolic process

organic substance catabolic process [inference]

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol metabolic process [inference]

inositol catabolic process

polyol catabolic process [inference]

inositol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol catabolic process

organic substance metabolic process [inference]

organic substance catabolic process [inference]

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol metabolic process [inference]

inositol catabolic process

polyol catabolic process [inference]

inositol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol catabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytosol
cytoplasm	ISS
inclusion body	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

intracellular anatomical structure [inference]

inclusion body

Displaying **all 4** entries
GO Term	Evidence Code	PMID
ferric iron binding	IDA	18364358
inositol oxygenase activity	IBA IDA ISS	18364358
oxidoreductase activity, acting on NAD(P)H	IEA
aldo-keto reductase (NADP) activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

inositol oxygenase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

aldo-keto reductase (NADP) activity

oxidoreductase activity, acting on NAD(P)H

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [inference]

inositol oxygenase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding [inference]

ferric iron binding

sulfur compound binding [inference]

ferric iron binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Inositol oxygenase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 5** entries
Gene Ontology
inositol catabolic process
inositol oxygenase activity
iron ion binding
metal ion binding
oxidoreductase activity

Displaying 1 entry
InterPro
Inositol oxygenase

KEGG BRITE Database

Orthology

K00469

Name

inositol oxygenase [EC:1.13.99.1]

References

11716759

Rhea

O₂ + myo-inositol

H₂O + H⁺ + D-glucuronate

Enzyme

1.13.99.1

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003601
Gene Name: myo-inositol oxygenase

Ortholog

Displaying entries **21 - 30** of 69 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Cricetulus griseus	100756277			CRIGR19464
Sarcophilus harrisii	100917358			SARHA16960
Otolemur garnettii	100962827			OTOGA17272
Pan paniscus	100971293	9597_0:0053a4		PANPA24161
Papio anubis	101004829			PAPAN12447
Saimiri boliviensis boliviensis	101042606			SAIBB20934
Takifugu rubripes	101067249			TAKRU52118
Felis catus	101081909			FELCA17151
Oryzias latipes	101174662			ORYLA15003
Tursiops truncatus	101338382			TURTR09242

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024