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solute carrier family 39 member 4

Summary

Gene Symbol

SLC39A4

Organism

Homo sapiens (human)

External Links

NCBI Gene

55630

PubChem

55630

Alliance of Genome Resources

HGNC:17129

Annotation

Keyword

Alternative splicing
Cadmium
Cell membrane
Disease variant
Disulfide bond
Endosome
Glycoprotein
Metal-binding
Reference proteome
Signal
Transmembrane helix
Ubl conjugation
Zinc transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6P5W5	Solute carrier family 39 member 4 Zrt- and Irt-like protein 4
Q9NX22

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
intracellular zinc ion homeostasis	ISS
bicarbonate transport	IEA
intracellular monoatomic cation homeostasis	IBA
cellular response to zinc ion starvation	IEA
zinc ion transmembrane transport	TAS

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to zinc ion starvation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to zinc ion starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to zinc ion starvation

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

zinc ion transmembrane transport

zinc ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

zinc ion transmembrane transport

zinc ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

zinc ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

zinc ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

zinc ion import across plasma membrane

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis

intracellular zinc ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis

intracellular zinc ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis

intracellular zinc ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis

intracellular zinc ion homeostasis

inorganic ion homeostasis [inference]

intracellular zinc ion homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to zinc ion starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to zinc ion starvation

response to zinc ion starvation [inference]

cellular response to zinc ion starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to zinc ion starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to zinc ion starvation

response to zinc ion starvation [inference]

cellular response to zinc ion starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to zinc ion starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to zinc ion starvation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to zinc ion starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to zinc ion starvation

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

zinc ion transport [inference]

zinc ion transmembrane transport

zinc ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

zinc ion transmembrane transport

zinc ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

zinc ion transmembrane transport

zinc ion import across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

zinc ion transmembrane transport

zinc ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

zinc ion transmembrane transport

zinc ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

zinc ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

zinc ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

zinc ion import across plasma membrane

organic substance transport [inference]

organic anion transport [inference]

bicarbonate transport

one-carbon compound transport [inference]

bicarbonate transport

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

zinc ion import across plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	14612438 30874431 31164399
plasma membrane	IBA
apical plasma membrane	ISS
cytoplasmic vesicle	IDA	14612438

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

recycling endosome membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

recycling endosome membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
zinc ion transmembrane transporter activity	TAS
zinc ion transmembrane transporter activity	IDA	22242765 31164399
zinc ion transmembrane transporter activity	IBA
zinc ion binding	IMP	25882556
identical protein binding	IDA	30874431

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

bicarbonate transmembrane transporter activity [inference]

monoatomic cation:bicarbonate symporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic cation:bicarbonate symporter activity

metal ion transmembrane transporter activity [inference]

transition metal ion transmembrane transporter activity [inference]

zinc ion transmembrane transporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic cation:bicarbonate symporter activity

inorganic molecular entity transmembrane transporter activity [inference]

bicarbonate transmembrane transporter activity [inference]

monoatomic cation:bicarbonate symporter activity

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

transition metal ion transmembrane transporter activity [inference]

zinc ion transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic cation:bicarbonate symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic cation:bicarbonate symporter activity

salt transmembrane transporter activity [inference]

zinc ion transmembrane transporter activity

bicarbonate transmembrane transporter activity [inference]

monoatomic cation:bicarbonate symporter activity

binding [inference]

protein binding [inference]

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

small molecule sensor activity [inference]

metal ion sensor activity [inference]

zinc ion sensor activity

molecular sequestering activity [inference]

metal ion sequestering activity [inference]

zinc ion sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Zinc transporter zip12

Functional Category

M: Cell wall/membrane/envelope biogenesis
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
metal ion transmembrane transporter activity
monoatomic cation
zinc ion transmembrane transporter activity

Displaying **all 3** entries
InterPro
Zinc transporter ZIP4, N-terminal
Zinc transporter ZIP4/12, EF-hand
Zinc/iron permease

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050605	acrodermatitis enteropathica	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 54 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	38976	RGD:1306701
Xenopus tropicalis	55630	Xenbase:XB-GENE-6049378
Mus musculus	72027	Xenbase:XB-GENE-6049378	MOUSE16483
Rattus norvegicus	300051	Xenbase:XB-GENE-6049378	RATNO39606
Pan troglodytes	464462		PANTR43489
Canis lupus familiaris	482096		CANLF03317
Bos taurus	510951		BOVIN05529
Macaca mulatta	708333		MACMU44635
Equus caballus	100147065		HORSE43122
Sus scrofa	100156896		PIGXX22678