GlyCosmos Portal

Submissions

Zinc transporter ZIP4

Summary

UniProt ID

Q6P5W5

Gene Symbol

SLC39A4
ZIP4

Gene ID

55630

Organism

Homo sapiens (human)

External Links

GlyGen: Q6P5W5
PubChem: Q6P5W5
The Human Metabolome Database: HMDBP11937
O-GlcNAcAtlas: Q6P5W5
Re-Glyco: Q6P5W5

Annotation

Keyword

Alternative splicing
Cadmium
Cell membrane
Disease variant
Disulfide bond
Endosome
Glycoprotein
Metal-binding
Reference proteome
Signal
Transmembrane helix
Ubl conjugation
Zinc transport

Gene Ontology (GO)

Displaying **all 4** entries
GO Term
apical plasma membrane
recycling endosome membrane
plasma membrane
cytoplasmic vesicle

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 5** entries
GO Term
cellular response to zinc ion starvation
intracellular monoatomic cation homeostasis
zinc ion transmembrane transport
zinc ion import across plasma membrane
intracellular zinc ion homeostasis

Displaying **all 7** entries
GO Term
zinc ion binding
metal ion binding
zinc ion transmembrane transporter activity
identical protein binding
monoatomic cation:bicarbonate symporter activity
zinc ion sensor activity
zinc ion sequestering activity

Annotation information from UniProt.

Sequence

MASLVSLELGLLLAVLVVTATASPPAGLLSLLTSGQGALDQEALGGLLNTLADRVHCANGPCGKCLSVEDALGLGEPEGSGLPPGPVLEARYVARLSAAAVLYLSNPEGTCEDARAGLWASHADHLLALLESPKALTPGLSWLLQRMQARAAGQTPKMACVDIPQLLEEAVGAGAPGSAGGVLAALLDHVRSGSCFHALPSPQYFVDFVFQQHSSEVPMTLAELSALMQRLGVGREAHSDHSHRHRGASSRDPVPLISSSNSSSVWDTVCLSARDVMAAYGLSEQAGVTPEAWAQLSPALLQQQLSGACTSQSRPPVQDQLSQSERYLYGSLATLLICLCAVFGLLLLTCTGCRGVTHYILQTFLSLAVGAVTGDAVLHLTPKVLGLHTHSEEGLSPQPTWRLLAMLAGLYAFFLFENLFNLLLPRDPEDLEDGPCGHSSHSHGGHSHGVSLQLAPSELRQPKPPHEGSRADLVAEESPELLNPEPRRLSPELRLLPYMITLGDAVHNFADGLAVGAAFASSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVRQALLLNLASALTAFAGLYVALAVGVSEESEAWILAVATGLFLYVALCDMLPAMLKVRDPRPWLLFLLHNVGLLGGWTVLLLLSLYEDDITF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
261	N-linked (GlcNAc...) asparagine	33837739		UniProt GlyGen
565			G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)	Homo sapiens
Zinc influx into cells by the SLC39 gene family	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050605	acrodermatitis enteropathica	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements