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adenosine deaminase, RNA-specific

Summary

Gene Symbol

Adar

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

56417

PubChem

56417

Alliance of Genome Resources

MGI:1889575

Annotation

Keyword

Alternative splicing
Antiviral defense
Cytoplasm
DNA-binding
Hydrolase
Innate immunity
Isopeptide bond
Metal-binding
Methylation
Nucleus
Phosphoprotein
RNA-binding
RNA-mediated gene silencing
Reference proteome
Repeat
Transcription regulation
Ubl conjugation
Zinc
mRNA processing

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q99MU3	RNA adenosine deaminase 1
Q3UH31

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
miRNA processing	IMP	23622242
cellular response to virus	IDA	24882218
RNA processing	IBA
erythrocyte differentiation	IMP	11099415
protein export from nucleus	ISO

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via somatic mutation

immune response [inference]

innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA processing

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

RNA modification [inference]

base conversion or substitution editing

adenosine to inosine editing

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA processing

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

RNA modification [inference]

base conversion or substitution editing

adenosine to inosine editing

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA processing

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

RNA modification [inference]

base conversion or substitution editing

adenosine to inosine editing

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA processing

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

RNA modification [inference]

base conversion or substitution editing

adenosine to inosine editing

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA processing

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

RNA modification [inference]

base conversion or substitution editing

adenosine to inosine editing

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule modification [inference]

RNA modification [inference]

base conversion or substitution editing

adenosine to inosine editing

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA processing

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

RNA modification [inference]

base conversion or substitution editing

adenosine to inosine editing

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA processing

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

RNA modification [inference]

base conversion or substitution editing

adenosine to inosine editing

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

epithelial cell apoptotic process [inference]

hepatocyte apoptotic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA processing

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

RNA modification [inference]

base conversion or substitution editing

adenosine to inosine editing

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA processing

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

RNA modification [inference]

base conversion or substitution editing

adenosine to inosine editing

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA processing

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

RNA modification [inference]

base conversion or substitution editing

adenosine to inosine editing

mRNA metabolic process [inference]

mRNA processing

ncRNA metabolic process [inference]

ncRNA processing [inference]

regulatory ncRNA processing [inference]

miRNA processing

pre-miRNA processing

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

cell development [inference]

hemopoiesis [inference]

definitive hemopoiesis

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

establishment of protein localization to organelle [inference]

protein import into nucleus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

RISC complex assembly

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

hematopoietic stem cell homeostasis

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

definitive hemopoiesis

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

cell development [inference]

hemopoiesis [inference]

definitive hemopoiesis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

hematopoietic stem cell homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

defense response to other organism [inference]

innate immune response

defense response to symbiont [inference]

defense response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

defense response to symbiont [inference]

defense response to virus

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

defense response to other organism [inference]

innate immune response

defense response to symbiont [inference]

defense response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

defense response to other organism [inference]

innate immune response

defense response to symbiont [inference]

defense response to virus

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to interferon-alpha

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

import into nucleus [inference]

protein import into nucleus

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

import into nucleus [inference]

protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

establishment of protein localization to organelle [inference]

protein import into nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of viral process [inference]

positive regulation of viral genome replication

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of hepatocyte apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of innate immune response [inference]

negative regulation of innate immune response [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of viral process [inference]

positive regulation of viral process [inference]

positive regulation of viral genome replication

regulation of viral life cycle [inference]

regulation of viral genome replication [inference]

positive regulation of viral genome replication

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of type I interferon-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of post-transcriptional gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of hepatocyte apoptotic process

regulation of epithelial cell apoptotic process [inference]

regulation of hepatocyte apoptotic process [inference]

negative regulation of hepatocyte apoptotic process

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of hepatocyte apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of hepatocyte apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of post-transcriptional gene silencing [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of gene silencing by regulatory ncRNA [inference]

negative regulation of post-transcriptional gene silencing by regulatory ncRNA

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of type I interferon-mediated signaling pathway

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of hepatocyte apoptotic process

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of transferase activity [inference]

regulation of kinase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

regulation of protein kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

negative regulation of transferase activity [inference]

negative regulation of kinase activity [inference]

negative regulation of protein kinase activity [inference]

negative regulation of protein kinase activity by regulation of protein phosphorylation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
supraspliceosomal complex	ISO ISS
nuclear speck	ISO
nucleoplasm	IEA ISO
nucleus	IDA ISO	14613934
cytoplasm	IBA IDA ISO	14613934

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

spliceosomal complex [inference]

supraspliceosomal complex

ribonucleoprotein complex [inference]

spliceosomal complex [inference]

supraspliceosomal complex

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying entries **1 - 5** of 7 in total

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2

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GO Term	Evidence Code	PMID
protein binding	IPI	18362360 21266480 28355180
double-stranded RNA binding	IBA
left-handed Z-DNA binding	TAS	11524677
metal ion binding	IEA
double-stranded RNA adenosine deaminase activity	IBA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [inference]

adenosine deaminase activity [inference]

deaminase activity [inference]

adenosine deaminase activity [inference]

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

double-stranded DNA binding [inference]

left-handed Z-DNA binding

double-stranded RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

double-stranded RNA-specific adenosine deaminase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 4** entries
Gene Ontology
adenosine deaminase activity
adenosine to inosine editing
double-stranded RNA binding
tRNA-specific adenosine deaminase activity

Displaying **all 7** entries
InterPro
ADAR1, first double-stranded RNA binding domain
ADAR1, third double-stranded RNA binding domain
Adenosine deaminase/editase
Double-stranded RNA-binding domain
Winged helix DNA-binding domain superfamily
Winged helix-like DNA-binding domain superfamily
Z-binding domain

Rhea

H₂O + H⁺

NH₄⁺

Enzyme

3.5.4.37

PMID

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050629	Aicardi-Goutieres syndrome	Alliance of Genome Resources
DOID:0060257	dyschromatosis symmetrica hereditaria	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:11166	Human papillomavirus infectious disease	Alliance of Genome Resources
DOID:3744	cervical squamous cell carcinoma	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources

Ortholog

Displaying entries **101 - 105** of **105** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Apodemus sylvaticus	127683085	10129_0:0015db
Peromyscus californicus insignis	128106201	564181_0:00535e
Psammomys obesus	129686854	48139_1:000477
Chionomys nivalis	130889383	269649_0:004353
Peromyscus eremicus	131913207	42410_0:00246b

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024