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pleckstrin and Sec7 domain containing

Summary

Gene Symbol

PSD

Organism

Homo sapiens (human)

External Links

NCBI Gene

5662

PubChem

5662

Alliance of Genome Resources

HGNC:9507

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Coiled coil
Guanine-nucleotide releasing factor
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A5PKW4	Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 Exchange factor for ARF6 A Pleckstrin homology and SEC7 domain-containing protein 1
Q86YI3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
signal transduction	NAS	9417912
neuron projection development	IEA
regulation of ARF protein signal transduction	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of ARF protein signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of ARF protein signal transduction

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of ARF protein signal transduction

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cleavage furrow	IDA	23603394
ruffle membrane	IDA	23603394
dendritic spine	IEA
postsynaptic density, intracellular component	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

cleavage furrow

leading edge membrane [inference]

ruffle membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

postsynapse [inference]

dendritic spine

Displaying **all 3** entries
GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	IDA	23603394
protein binding	IPI	20339350
phospholipid binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

PH and SEC7 domain-containing protein 1

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
phospholipid binding
regulation of ARF protein signal transduction

Displaying **all 7** entries
InterPro
PH-like domain superfamily
Pleckstrin homology domain 9
Pleckstrin homology domain, spectrin-type
Pleckstrin homology domain
Sec7 domain superfamily
Sec7 domain
Sec7, C-terminal domain superfamily

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5662	Xenbase:XB-GENE-6467347
Saccharomyces cerevisiae S288C	23096	SGD:S000006299
Mus musculus	73728		MOUSE26510
Rattus norvegicus	171381		RATNO19834
Saccharomyces cerevisiae S288C	232227	SGD:S000006299
Saccharomyces cerevisiae S288C	234353	SGD:S000006299
Saccharomyces cerevisiae S288C	245666	SGD:S000006299
Saccharomyces cerevisiae S288C	440073	SGD:S000006299
Canis lupus familiaris	486859		CANLF11425
Bos taurus	523124		BOVIN21419