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mitochondrial fission factor

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

56947

PubChem

56947

Alliance of Genome Resources

HGNC:24858

Annotation

Keyword

Alternative splicing
Coiled coil
Cytoplasmic vesicle
Mitochondrion outer membrane
Peroxisome
Phosphoprotein
Proteomics identification
Reference proteome
Synapse
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A9L9PY92
A0A0A0MS29
Q9GZY8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
mitochondrial fission	ISS
mitochondrial fission	IDA	23283981 23530241
mitochondrial fission	IMP	18353969 21149567
protein targeting to mitochondrion	ISS
protein targeting to mitochondrion	IDA	23283981

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

mitochondrial fission

organelle fission [inference]

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fission

positive regulation of developmental process [inference]

positive regulation of mitochondrial fission

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of mitochondrial fission [inference]

positive regulation of mitochondrial fission

positive regulation of developmental process [inference]

positive regulation of mitochondrial fission

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fission

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fission

regulation of mitochondrion organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fission

regulation of mitochondrial fission [inference]

positive regulation of mitochondrial fission

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fission

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
mitochondrion	IDA
mitochondrion	HTP	34800366
mitochondrial outer membrane	IDA	21149567
mitochondrial outer membrane	IBA
peroxisome	IDA	18353969 23921378

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21149567 26358295 29464060 32296183 36217029
identical protein binding	IPI	18353969 32296183
protein homodimerization activity	IDA	23530241

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Mitochondrial fission factor

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
mitochondrial fission
positive regulation of mitochondrial fission
positive regulation of protein targeting to membrane

Displaying **all 2** entries
InterPro
Mff-like domain
Mff/Tango-11

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060994	encephalopathy due to defective mitochondrial and peroxisomal fission 2	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	7038	Xenbase:XB-GENE-5870242
Xenopus tropicalis	21819	Xenbase:XB-GENE-5870242
Xenopus tropicalis	56947	Xenbase:XB-GENE-5870242
Mus musculus	75734	Xenbase:XB-GENE-5870242	MOUSE27573
Rattus norvegicus	301563		RATNO43097
Pan troglodytes	459989		PANTR29922
Bos taurus	506291		BOVIN24855
Macaca mulatta	708489		MACMU06384
Monodelphis domestica	100014883		MONDO32605
Equus caballus	100056853		HORSE36105