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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
phosphatase and tensin homolog
Summary
- Gene Symbol
-
- PTEN
- Aliases
-
- MMAC1
- PTEN1
- TEP1
- mutated in multiple advanced cancers 1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative initiation
- Alternative splicing
- Apoptosis
- Autism spectrum disorder
- Cell projection
- Cytoplasm
- Disease variant
- Isopeptide bond
- Lipid metabolism
- Lipid-binding
- Neurogenesis
- Nucleus
- Phosphoprotein
- Protein phosphatase
- Reference proteome
- Secreted
- Synapse
- Tumor suppressor
- Ubl conjugation
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of wound healing, spreading of epidermal cells | ||
| learning or memory | ||
| negative regulation of peptidyl-serine phosphorylation | ||
| negative regulation of vascular associated smooth muscle cell proliferation | ||
| neuron-neuron synaptic transmission |
GO Hierarchy
- negative regulation of excitatory postsynaptic potential
biological process
metabolic process [inference]
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of phosphorus metabolic process [inference]
negative regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of phosphorus metabolic process [inference]
negative regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cell cycle [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| postsynaptic density | ||
| apical plasma membrane | ||
| myelin sheath adaxonal region | ||
| plasma membrane | ||
| cell projection |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| phosphatidylinositol phosphate phosphatase activity | ||
| protein binding | ||
| enzyme binding | ||
| molecular function inhibitor activity | ||
| protein tyrosine phosphatase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- phosphatase
- Functional Category
-
- E: Amino acid transport and metabolism
- P: Inorganic ion transport and metabolism
- T: Signal transduction mechanisms
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:684 | hepatocellular carcinoma | |
| DOID:76 | stomach disease | |
| DOID:8029 | sporadic breast cancer | |
| DOID:8719 | in situ carcinoma | |
| DOID:8805 | intermediate coronary syndrome | |
| DOID:8947 | diabetic retinopathy | |
| DOID:8991 | cervix uteri carcinoma in situ | |
| DOID:9256 | colorectal cancer | |
| DOID:9351 | diabetes mellitus | |
| DOID:936 | brain disease |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000034 | Hydrocele testis |
| HP:0000036 | Abnormal penis morphology |
| HP:0000040 | Long penis |
| HP:0000053 | Macroorchidism |
| HP:0000077 | Abnormality of the kidney |
| HP:0000098 | Tall stature |
| HP:0000105 | Enlarged kidney |
| HP:0000107 | Renal cyst |
| HP:0000130 | Abnormality of the uterus |
| Disease ID | Disease Name |
|---|---|
| OMIM:605309 |
|
| OMIM:176807 |
|
| ORPHA:65285 |
|
| ORPHA:210548 |
|
| OMIM:613028 |
|
| ORPHA:2969 |
|
| OMIM:607174 |
|
| ORPHA:109 |
|
| ORPHA:137608 |
|
| ORPHA:397596 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP000810
- Gene Name
- phosphatase and tensin homolog
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 100660561 | LOXAF15638 | |||
| 100695712 | ORENI14286 | |||
| 100983152 | 9597_0:002b09 | |||
| 101016586 | PAPAN03020 | |||
| 101039215 | SAIBB04613 | |||
| 101091813 | FELCA26459 | |||
| 101119351 | SHEEP11412 | |||
| 101147526 | 9595_0:002e76 | |||
| 101171856 | ORYLA04962 | |||
| 101798136 | ANAPP22764 |
