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SUMO specific peptidase 7

Summary

Gene Symbol

SENP7

Organism

Homo sapiens (human)

External Links

NCBI Gene

57337

PubChem

57337

Alliance of Genome Resources

HGNC:30402

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Hydrolase
Innate immunity
Phosphoprotein
Proteomics identification
Reference proteome
Thiol protease
Ubl conjugation pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
J3QT09
Q9BQF6	SUMO-1-specific protease 2 Sentrin/SUMO-specific protease SENP7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
proteolysis	IEA
protein desumoylation	IBA ISS
antiviral innate immune response	ISS

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response [inference]

antiviral innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein desumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein desumoylation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein desumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein desumoylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein desumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein desumoylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein desumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein desumoylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein desumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein desumoylation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

antiviral innate immune response

defense response to other organism [inference]

innate immune response [inference]

antiviral innate immune response

defense response to symbiont [inference]

defense response to virus [inference]

antiviral innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

antiviral innate immune response

defense response to symbiont [inference]

defense response to virus [inference]

antiviral innate immune response

immune response [inference]

innate immune response [inference]

antiviral innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

antiviral innate immune response

defense response to other organism [inference]

innate immune response [inference]

antiviral innate immune response

defense response to symbiont [inference]

defense response to virus [inference]

antiviral innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus [inference]

antiviral innate immune response

defense response to other organism [inference]

innate immune response [inference]

antiviral innate immune response

defense response to symbiont [inference]

defense response to virus [inference]

antiviral innate immune response

Displaying **all 4** entries
GO Term	Evidence Code	PMID
presynaptic cytosol	IEA
postsynaptic cytosol	IEA
nucleus	IBA IDA
cytoplasm	IBA ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cytosol [inference]

cytosolic region [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	20562864 24018422 27705803
SUMO-specific endopeptidase activity	IBA ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

ubiquitin-like protein peptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

ubiquitin-like protein peptidase activity [inference]

ubiquitin-like protein-specific endopeptidase activity [inference]

SUMO-specific endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sentrin-specific protease

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
SUMO-specific endopeptidase activity
hydrolase activity
proteolysis

Displaying **all 2** entries
InterPro
Papain-like cysteine peptidase superfamily
Ulp1 protease family, C-terminal catalytic domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060318	acute promyelocytic leukemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	32229		FB:FBgn0030420
Mus musculus	66315		MGI:1913565	MOUSE18132
Caenorhabditis elegans	174307		WB:WBGene00006739
Rattus norvegicus	288167		RGD:1305510	RATNO04496
Canis lupus familiaris	487955			CANLF13246
Bos taurus	507820			BOVIN14414
Danio rerio	571373		ZFIN:ZDB-GENE-070912-345
Macaca mulatta	701453			MACMU28557
Pan troglodytes	740121	9598_0:00102c		PANTR31730
Saccharomyces cerevisiae S288C	854780		SGD:S000001293

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024