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protein tyrosine phosphatase non-receptor type 1
Summary
- Gene Symbol
-
- PTPN1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Direct protein sequencing
- Endoplasmic reticulum
- Membrane
- Oxidation
- Phosphoprotein
- Protein phosphatase
- Proteomics identification
- Receptor
- Reference proteome
- S-nitrosylation
- Transmembrane helix
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of MAP kinase activity | ||
| positive regulation of JUN kinase activity | ||
| cellular response to fibroblast growth factor stimulus | ||
| negative regulation of insulin receptor signaling pathway | ||
| negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO Hierarchy
- regulation of hepatocyte growth factor receptor signaling pathway
- regulation of hepatocyte growth factor receptor signaling pathway
- regulation of hepatocyte growth factor receptor signaling pathway
biological process
cellular process [inference]
response to stimulus [inference]
response to stress [inference]
response to endogenous stimulus [inference]
response to chemical [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction
negative regulation of signal transduction
regulation of endoplasmic reticulum unfolded protein response [inference]
regulation of intracellular signal transduction [inference]
negative regulation of signaling [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of signaling [inference]
negative regulation of cellular process [inference]
negative regulation of response to stimulus [inference]
regulation of response to stimulus [inference]
regulation of signal transduction
negative regulation of signal transduction
regulation of endoplasmic reticulum unfolded protein response [inference]
regulation of intracellular signal transduction [inference]
negative regulation of response to stimulus [inference]
regulation of response to stress [inference]
regulation of cellular process [inference]
signal transduction [inference]
regulation of cell communication [inference]
regulation of signal transduction
negative regulation of signal transduction
regulation of endoplasmic reticulum unfolded protein response [inference]
regulation of intracellular signal transduction [inference]
negative regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of programmed cell death [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cellular response to stress [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| early endosome | ||
| endoplasmic reticulum | ||
| endoplasmic reticulum | ||
| cytosol | ||
| cytosol |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| histone H2AXY142 phosphatase activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Protein tyrosine phosphatase
- Functional Category
-
- G: Carbohydrate transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| dephosphorylation |
| protein dephosphorylation |
| protein tyrosine phosphatase activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10825 | essential hypertension | |
| DOID:3393 | coronary artery disease | |
| DOID:9352 | type 2 diabetes mellitus |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 5770 | Xenbase:XB-GENE-950442 | ||
| 5771 | SGD:S000002389 | ||
| 5778 | SGD:S000002389 | ||
| 19246 | MOUSE34595 | ||
| 19255 | FB:FBgn0267487 | ||
| 24697 | RATNO27199 | ||
| 469970 | PANTR25128 | ||
| 477263 | CANLF09651 | ||
| 508658 | BOVIN05453 | ||
| 702016 | MACMU01260 |
