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protein tyrosine phosphatase receptor type B

Summary

Gene Symbol

PTPRB

Organism

Homo sapiens (human)

External Links

NCBI Gene

5787

PubChem

5787

Alliance of Genome Resources

HGNC:9665

Annotation

Keyword

3D-structure
Alternative splicing
Angiogenesis
Glycoprotein
Phosphoprotein
Protein phosphatase
Proteomics identification
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q68D73
F8VU56
P23467	Vascular endothelial protein tyrosine phosphatase
Q86VA4

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
angiogenesis	IBA
osteoblast differentiation	IDA	22869525
chromatin remodeling	IEA
protein dephosphorylation	TAS	2170109
phosphate-containing compound metabolic process	TAS	2170109

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process

dephosphorylation

protein dephosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process

dephosphorylation

protein dephosphorylation

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cell motility [inference]

cell migration [inference]

glial cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IC	22869525
specific granule membrane	TAS
receptor complex	IDA	23382219
receptor complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

bounding membrane of organelle [inference]

secretory granule membrane [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
non-membrane spanning protein tyrosine phosphatase activity	IEA
transmembrane receptor protein tyrosine phosphatase activity	TAS	2170109
protein binding	IPI	12840032 12907755 16101282 19167335 19451274 28065597 31980649
protein tyrosine phosphatase activity, metal-dependent	IEA
cadherin binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity [inference]

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity [inference]

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

histone modifying activity [inference]

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

binding [inference]

protein binding

cell adhesion molecule binding [inference]

cadherin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Receptor-type tyrosine-protein phosphatase beta

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
angiogenesis
cadherin binding

Displaying **all 4** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
PTPRJ, transmembrane domain

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0001816	angiosarcoma	Alliance of Genome Resources
DOID:0060108	brain glioma	Alliance of Genome Resources
DOID:0080199	colorectal carcinoma	Alliance of Genome Resources
DOID:1115	sarcoma	Alliance of Genome Resources
DOID:3068	glioblastoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources
DOID:4511	breast angiosarcoma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5787	Xenbase:XB-GENE-991728
Mus musculus	19263	Xenbase:XB-GENE-991728	MOUSE01567
Xenopus tropicalis	32115	Xenbase:XB-GENE-991728
Xenopus tropicalis	174437	Xenbase:XB-GENE-991728
Rattus norvegicus	314843		RATNO37730
Pan troglodytes	452074		PANTR06404
Canis lupus familiaris	481162		CANLF01422
Bos taurus	505696		BOVIN29412
Caenorhabditis elegans	545902	WB:WBGene00009717
Macaca mulatta	718564		MACMU04577

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OrthoDB (Group)

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Acknowledgements