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protein tyrosine phosphatase receptor type D

Summary

Gene Symbol

PTPRD

Organism

Homo sapiens (human)

External Links

NCBI Gene

5789

KEGG Gene ID

PubChem

5789

Alliance of Genome Resources

HGNC:9668

Annotation

Keyword

3D-structure
Alternative splicing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Protein phosphatase
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q3KPI9
Q2HXI4
Q59H90
P23468

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
phosphate-containing compound metabolic process	NAS
heterophilic cell-cell adhesion
signal transduction	IBA
cell surface receptor protein tyrosine phosphatase signaling pathway	TAS
cell surface receptor protein tyrosine phosphatase signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling

trans-synaptic signaling by trans-synaptic complex

cell adhesion [inference]

cell-cell adhesion [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine phosphatase signaling pathway

metabolic process [inference]

phosphate-containing compound metabolic process

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

membrane assembly [inference]

presynaptic membrane assembly

presynapse assembly

membrane organization [inference]

membrane assembly [inference]

presynaptic membrane assembly

presynaptic membrane organization [inference]

presynaptic membrane assembly

presynapse organization [inference]

presynapse assembly

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

animal gross anatomical part developmental process [inference]

nervous system development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling

trans-synaptic signaling by trans-synaptic complex

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of synapse assembly

positive regulation of dendritic spine development [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of synapse assembly

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

regulation of immune response

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of dendrite morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of dendritic spine morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of dendrite development [inference]

regulation of dendrite morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of synapse assembly

positive regulation of dendritic spine development [inference]

positive regulation of dendritic spine morphogenesis

regulation of dendritic spine development [inference]

positive regulation of dendritic spine development [inference]

positive regulation of dendritic spine morphogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of synapse assembly

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine phosphatase signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

regulation of excitatory synapse assembly [inference]

regulation of postsynaptic density assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of organelle assembly [inference]

regulation of postsynaptic specialization assembly [inference]

regulation of postsynaptic density assembly

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of receptor signaling pathway via STAT [inference]

negative regulation of receptor signaling pathway via JAK-STAT

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendritic spine morphogenesis

regulation of dendrite development [inference]

regulation of dendrite morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of dendritic spine morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of organelle organization [inference]

regulation of organelle assembly [inference]

regulation of postsynaptic specialization assembly [inference]

regulation of postsynaptic density assembly

regulation of postsynaptic density organization [inference]

regulation of postsynaptic density assembly

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

regulation of excitatory synapse assembly [inference]

regulation of postsynaptic density assembly

regulation of postsynapse organization [inference]

regulation of dendritic spine morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of postsynaptic density organization [inference]

regulation of postsynaptic density assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

regulation of excitatory synapse assembly [inference]

regulation of postsynaptic density assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of synapse assembly

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IEA
membrane	IEA
presynaptic membrane
extracellular exosome	HDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein tyrosine phosphatase activity	IBA
protein tyrosine phosphatase activity	IEA
transmembrane receptor protein tyrosine phosphatase activity	TAS
transmembrane receptor protein tyrosine phosphatase activity	IEA
signaling receptor binding	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

transmembrane receptor protein tyrosine phosphatase activity

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

transmembrane receptor protein tyrosine phosphatase activity

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:9351	diabetes mellitus	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	19266	MGI:97812
Caenorhabditis elegans	174685	WB:WBGene00004215
Drosophila melanogaster	35259	FB:FBgn0000464

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements