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Guidelines

MIRAGE

Protein-tyrosine-phosphatase;Tyrosine-protein phosphatase Lar-like;protein-tyrosine-phosphatase

Summary

Gene Symbol

ptp-3

Organism

Caenorhabditis elegans

External Links

NCBI Gene

174685

PubChem

174685

Alliance of Genome Resources

WB:WBGene00004215

Annotation

Keyword

Alternative splicing
Cell junction
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Protein phosphatase
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix

Proteins

Displaying **all 8** entries
UniProt	Protein Name
L8E6W1
G5EE54
L8E6H9
L8E7X5
L8E6L2
Q9BMN8	Protein-tyrosine phosphate 3
L8E6Z3
Q8I120

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
neuron migration	IMP	23051647
protein dephosphorylation	ISS
protein dephosphorylation	IEA
signal transduction	IBA
gastrulation	IMP	11959824

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular process [inference]

signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

cell motility [inference]

cell migration [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to synapse

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

motor neuron axon guidance

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

body morphogenesis [inference]

embryonic body morphogenesis

embryonic morphogenesis [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

system development [inference]

nervous system development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to synapse

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to synapse

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
plasma membrane	IEA
adherens junction	IDA	11959824
adherens junction	IMP	11959824
adherens junction	IEA
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

plasma membrane

cell junction [inference]

synapse

anchoring junction

cell-cell junction [inference]

adherens junction

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
phosphoprotein phosphatase activity	IEA
protein tyrosine phosphatase activity	ISS
protein tyrosine phosphatase activity	IDA	32513699
protein tyrosine phosphatase activity	IBA
protein tyrosine phosphatase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

histone modifying activity [inference]

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Tyrosine phosphatase

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
dephosphorylation
protein tyrosine phosphatase activity

Displaying **all 5** entries
InterPro
Protein-tyrosine phosphatase, active site
Protein-tyrosine phosphatase, catalytic
Protein-tyrosine phosphatase-like
Tyrosine-specific protein phosphatase, PTPase domain
Tyrosine-specific protein phosphatases domain

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
synaptic vesicle	PMID:33147118
synapse	PMID:16107639
adherens junction	PMID:11959824

Ortholog

Displaying entries **1 - 10** of 11 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5789	Xenbase:XB-GENE-478374
Xenopus tropicalis	5792	Xenbase:XB-GENE-495325
Xenopus tropicalis	5802	Xenbase:XB-GENE-478236
Xenopus tropicalis	19266	Xenbase:XB-GENE-478374
Xenopus tropicalis	19268	Xenbase:XB-GENE-495325
Xenopus tropicalis	19280	Xenbase:XB-GENE-478236
Xenopus tropicalis	25529	Xenbase:XB-GENE-478236
Xenopus tropicalis	35259	Xenbase:XB-GENE-495325
Xenopus tropicalis	174685	Xenbase:XB-GENE-495325
Xenopus tropicalis	360406	Xenbase:XB-GENE-495325

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Last updated: April 7, 2025