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protein tyrosine phosphatase receptor type O

Summary

Gene Symbol

PTPRO

Organism

Homo sapiens (human)

External Links

NCBI Gene

5800

PubChem

5800

Alliance of Genome Resources

HGNC:9678

Annotation

Keyword

3D-structure
Alternative splicing
Glycoprotein
Phosphoprotein
Protein phosphatase
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q16827	Glomerular epithelial protein 1 Protein tyrosine phosphatase U2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 17 in total

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GO Term	Evidence Code	PMID
slit diaphragm assembly	ISS NAS	20633639
peptidyl-tyrosine dephosphorylation	IMP	19233845
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	IEA
podocyte differentiation	IBA ISS
negative regulation of canonical Wnt signaling pathway	IBA ISS

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

monocyte chemotaxis

mononuclear cell migration [inference]

monocyte chemotaxis

myeloid leukocyte migration [inference]

monocyte chemotaxis

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epithelial cell differentiation involved in kidney development [inference]

glomerular epithelial cell differentiation [inference]

podocyte differentiation

cell differentiation involved in kidney development [inference]

epithelial cell differentiation involved in kidney development [inference]

glomerular epithelial cell differentiation [inference]

podocyte differentiation

renal filtration cell differentiation [inference]

podocyte differentiation

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

monocyte chemotaxis

mononuclear cell migration [inference]

monocyte chemotaxis

myeloid leukocyte migration [inference]

monocyte chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

monocyte chemotaxis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell junction assembly [inference]

cell-cell junction assembly [inference]

filtration diaphragm assembly [inference]

slit diaphragm assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

lamellipodium organization [inference]

lamellipodium assembly

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

filtration diaphragm assembly [inference]

slit diaphragm assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

filtration diaphragm assembly [inference]

slit diaphragm assembly

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal system process involved in regulation of systemic arterial blood pressure [inference]

renal system process involved in regulation of blood volume [inference]

regulation of glomerular filtration

negative regulation of glomerular filtration

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

anatomical structure development [inference]

glomerulus development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epithelial cell differentiation involved in kidney development [inference]

glomerular epithelial cell differentiation [inference]

podocyte differentiation

cell differentiation involved in kidney development [inference]

epithelial cell differentiation involved in kidney development [inference]

glomerular epithelial cell differentiation [inference]

podocyte differentiation

renal filtration cell differentiation [inference]

podocyte differentiation

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

monocyte chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of axon guidance [inference]

regulation of retinal ganglion cell axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

negative regulation of multicellular organismal process [inference]

negative regulation of glomerular filtration

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of axon guidance [inference]

regulation of retinal ganglion cell axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

regulation of cell-substrate adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of axon guidance [inference]

regulation of retinal ganglion cell axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of synapse organization

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of renal system process [inference]

regulation of glomerular filtration

negative regulation of glomerular filtration

negative regulation of multicellular organismal process [inference]

negative regulation of glomerular filtration

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
membrane	TAS	10498613
postsynaptic density membrane	IEA
lateral plasma membrane	ISS
apical plasma membrane	ISS
plasma membrane	IBA ISS NAS	7665166

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

lateral plasma membrane

cell junction [inference]

synapse [inference]

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

neuron projection

axon

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
transmembrane receptor protein tyrosine phosphatase activity	NAS	7665166
protein binding	IPI	19167335 28330616
protein tyrosine phosphatase activity	IBA IDA IMP TAS	10498613 19167335 19233845
phosphatase activity	ISS
Wnt-protein binding	IBA ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

transmembrane receptor protein tyrosine phosphatase activity

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

transmembrane receptor protein tyrosine phosphatase activity

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

binding [inference]

protein binding

Wnt-protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding [inference]

cadherin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor-type tyrosine-protein phosphatase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
dephosphorylation
protein tyrosine phosphatase activity

Displaying **all 5** entries
InterPro
Protein-tyrosine phosphatase, active site
Protein-tyrosine phosphatase, catalytic
Protein-tyrosine phosphatase-like
Tyrosine-specific protein phosphatase, PTPase domain
Tyrosine-specific protein phosphatases domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080384	nephrotic syndrome type 6	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of 60 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Athene cunicularia	113491206		ATHCN06553
Bos indicus x Bos taurus	113892527		BOBOX39876
Vombatus ursinus	114025312		VOMUR06317
Podarcis muralis	114605089		PODMU34966
Echeneis naucrates	115036497		ECHNA42093
Salmo trutta	115189853		SALTR48457
Corvus moneduloides	116443604		CORMO20541
Chelonoidis abingdonii	116819078		CHEAB20066
Rhinolophus ferrumequinum	117029455		RHIFE10122
Pongo pygmaeus	129010641	9600_0:0032de

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OrthoDB (Group)

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Acknowledgements