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protein tyrosine phosphatase receptor type O

Summary

Gene Symbol

PTPRO

Organism

Homo sapiens (human)

External Links

NCBI Gene

5800

PubChem

5800

Alliance of Genome Resources

HGNC:9678

Annotation

Keyword

3D-structure
Alternative splicing
Glycoprotein
Phosphoprotein
Protein phosphatase
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q16827	Glomerular epithelial protein 1 Protein tyrosine phosphatase U2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
negative regulation of neuron projection development	ISS
protein dephosphorylation	ISS TAS	10498613
monocyte chemotaxis	IMP	19233845
cell morphogenesis	ISS
peptidyl-tyrosine dephosphorylation	IMP	19233845

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

monocyte chemotaxis

mononuclear cell migration [inference]

monocyte chemotaxis

myeloid leukocyte migration [inference]

monocyte chemotaxis

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epithelial cell differentiation involved in kidney development [inference]

glomerular epithelial cell differentiation [inference]

podocyte differentiation

cell differentiation involved in kidney development [inference]

epithelial cell differentiation involved in kidney development [inference]

glomerular epithelial cell differentiation [inference]

podocyte differentiation

renal filtration cell differentiation [inference]

podocyte differentiation

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

monocyte chemotaxis

mononuclear cell migration [inference]

monocyte chemotaxis

myeloid leukocyte migration [inference]

monocyte chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

monocyte chemotaxis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell junction assembly [inference]

cell-cell junction assembly [inference]

filtration diaphragm assembly [inference]

slit diaphragm assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

lamellipodium organization [inference]

lamellipodium assembly

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

filtration diaphragm assembly [inference]

slit diaphragm assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

filtration diaphragm assembly [inference]

slit diaphragm assembly

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal system process involved in regulation of systemic arterial blood pressure [inference]

renal system process involved in regulation of blood volume [inference]

regulation of glomerular filtration

negative regulation of glomerular filtration

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

anatomical structure development [inference]

glomerulus development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epithelial cell differentiation involved in kidney development [inference]

glomerular epithelial cell differentiation [inference]

podocyte differentiation

cell differentiation involved in kidney development [inference]

epithelial cell differentiation involved in kidney development [inference]

glomerular epithelial cell differentiation [inference]

podocyte differentiation

renal filtration cell differentiation [inference]

podocyte differentiation

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

monocyte chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of axon guidance [inference]

regulation of retinal ganglion cell axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

negative regulation of multicellular organismal process [inference]

negative regulation of glomerular filtration

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of axon guidance [inference]

regulation of retinal ganglion cell axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

regulation of cell-substrate adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of axon guidance [inference]

regulation of retinal ganglion cell axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of synapse organization

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axon guidance [inference]

negative regulation of retinal ganglion cell axon guidance

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of renal system process [inference]

regulation of glomerular filtration

negative regulation of glomerular filtration

negative regulation of multicellular organismal process [inference]

negative regulation of glomerular filtration

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
lamellipodium	ISS
apical plasma membrane	ISS
glutamatergic synapse	IBA
axon	ISS
lateral plasma membrane	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

lateral plasma membrane

cell junction [inference]

synapse [inference]

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

neuron projection

axon

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

postsynapse [inference]

dendritic spine

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
protein homodimerization activity	ISS
transmembrane receptor protein tyrosine phosphatase activity	NAS	7665166

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

transmembrane receptor protein tyrosine phosphatase activity

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

transmembrane receptor protein tyrosine phosphatase activity

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

binding [inference]

protein binding

Wnt-protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding [inference]

cadherin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080384	nephrotic syndrome type 6	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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