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RAD51 paralog C

Summary

Gene Symbol

RAD51C

Organism

Homo sapiens (human)

External Links

NCBI Gene

5889

PubChem

5889

Alliance of Genome Resources

HGNC:9820

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cytoplasm
DNA recombination
DNA repair
DNA-binding
Disease variant
Fanconi anemia
Mitochondrion
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O43502	RAD51 homolog C RAD51-like protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
meiotic DNA recombinase assembly	IBA
telomere maintenance via recombination	IEA
double-strand break repair via homologous recombination	IMP	23149936
DNA repair	IDA	19451272
DNA recombination	IDA	19451272

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

cellular process [inference]

cell cycle process [inference]

sister chromatid cohesion

meiotic sister chromatid cohesion [inference]

female meiosis sister chromatid cohesion

meiotic cell cycle process [inference]

reciprocal meiotic recombination

meiosis I cell cycle process [inference]

meiotic DNA recombinase assembly

meiosis I [inference]

male meiosis I

meiotic nuclear division [inference]

meiosis I [inference]

male meiosis I

male meiotic nuclear division [inference]

male meiosis I

cellular process involved in reproduction in multicellular organism [inference]

male meiotic nuclear division [inference]

male meiosis I

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

mitotic recombination [inference]

telomere maintenance via recombination

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle fission [inference]

nuclear division [inference]

meiotic nuclear division [inference]

meiosis I [inference]

male meiosis I

male meiotic nuclear division [inference]

male meiosis I

chromosome organization [inference]

sister chromatid cohesion

meiotic sister chromatid cohesion [inference]

female meiosis sister chromatid cohesion

telomere organization [inference]

telomere maintenance [inference]

telomere maintenance via recombination

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

DNA recombinase assembly [inference]

meiotic DNA recombinase assembly

DNA repair complex assembly [inference]

DNA recombinase assembly [inference]

meiotic DNA recombinase assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

DNA recombinase assembly [inference]

meiotic DNA recombinase assembly

DNA repair complex assembly [inference]

DNA recombinase assembly [inference]

meiotic DNA recombinase assembly

protein-DNA complex organization [inference]

protein-DNA complex assembly [inference]

DNA recombinase assembly [inference]

meiotic DNA recombinase assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

cellular process involved in reproduction in multicellular organism [inference]

male meiotic nuclear division [inference]

male meiosis I

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

meiotic cell cycle process [inference]

reciprocal meiotic recombination

meiosis I cell cycle process [inference]

meiotic DNA recombinase assembly

meiosis I [inference]

male meiosis I

meiotic nuclear division [inference]

meiosis I [inference]

male meiosis I

male meiotic nuclear division [inference]

male meiosis I

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of cell cycle process [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of cell cycle phase transition [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

regulation of cell cycle G2/M phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

positive regulation of cell cycle G2/M phase transition [inference]

positive regulation of G2/M transition of mitotic cell cycle

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	12966089 16215984
nucleoplasm	TAS
nucleoplasm	IDA
replication fork	IDA	20207730
replication fork	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

DNA recombinase mediator complex [inference]

nuclear protein-containing complex [inference]

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
four-way junction DNA binding	IDA	20207730
four-way junction DNA binding	IBA
DNA binding	TAS	9469824
protein binding	IPI	11751635 11842113 16395335 21965664 24005329 24141787 26496610 28514442 28864920 32296183 33961781 34591612 35849344 9469824
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

crossover junction DNA endonuclease activity

endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

crossover junction DNA endonuclease activity

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

crossover junction DNA endonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

crossover junction DNA endonuclease activity

ATP-dependent activity, acting on DNA [inference]

ATP-dependent DNA damage sensor activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

DNA secondary structure binding [inference]

four-way junction DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

small molecule sensor activity [inference]

DNA damage sensor activity [inference]

ATP-dependent DNA damage sensor activity

ATP-dependent activity [inference]

ATP-dependent activity, acting on DNA [inference]

ATP-dependent DNA damage sensor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA repair protein

Functional Category

L: Replication, recombination and repair
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 6** entries
Gene Ontology
ATP binding
ATP-dependent DNA damage sensor activity
DNA repair
four-way junction DNA binding
meiotic DNA recombinase assembly
nucleotide binding

Displaying **all 3** entries
InterPro
DNA recombination and repair protein Rad51-like, C-terminal
DNA recombination and repair protein RecA-like, ATP-binding domain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111096	Fanconi anemia complementation group O	Alliance of Genome Resources
DOID:5683	hereditary breast ovarian cancer syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 58 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5889	Xenbase:XB-GENE-1015191
Mus musculus	114714		MOUSE06289
Danio rerio	450081		DANRE01394
Pan troglodytes	455162		PANTR15041
Canis lupus familiaris	480573		CANLF18950
Rattus norvegicus	497976		RATNO01421
Bos taurus	540886		BOVIN12162
Macaca mulatta	714828		MACMU14237
Monodelphis domestica	100011576		MONDO12491
Equus caballus	100070966		HORSE04282

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements