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Guidelines

MIRAGE

retinol dehydrogenase 5

Summary

Gene Symbol

RDH5

Organism

Homo sapiens (human)

External Links

NCBI Gene

5959

PubChem

5959

Alliance of Genome Resources

HGNC:9940

JoGo

RDH5

TogoVar

RDH5

Annotation

Keyword

Disease variant
Endoplasmic reticulum
Glycoprotein
NAD
Oxidoreductase
Proteomics identification
Reference proteome
Steroid metabolism
Transmembrane helix
Vision

Proteins

Displaying 1 entry
UniProt	Protein Name
Q92781	11-cis retinol dehydrogenase 9-cis retinol dehydrogenase Short chain dehydrogenase/reductase family 9C member 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
retinoid metabolic process	TAS
retinoid metabolic process	IDA	9931293
retinoid metabolic process	IBA
visual perception	IEA
steroid metabolic process	IDA	9931293

GO Hierarchy

biological process

metabolic process [inference]

hormone metabolic process [inference]

retinol metabolic process

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

olefinic compound metabolic process [inference]

retinol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinol metabolic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	IDA	11675386
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IDA	11675386
intracellular membrane-bounded organelle	IBA
cell body	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

cell body

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
NAD-retinol dehydrogenase activity	TAS
NAD-retinol dehydrogenase activity	IDA	11675386
NAD-retinol dehydrogenase activity	IBA
protein homodimerization activity	IDA	11675386
androsterone dehydrogenase activity	IDA	9931293

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

NAD-retinol dehydrogenase activity

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

11-cis-retinol dehydrogenase

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
oxidoreductase activity
steroid metabolic process

Displaying **all 2** entries
InterPro
NAD(P)-binding domain superfamily
Short-chain dehydrogenase/reductase SDR

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:11105	fundus albipunctatus	Alliance of Genome Resources
DOID:8499	night blindness	Alliance of Genome Resources

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025