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Guidelines

MIRAGE

retinol dehydrogenase 5

Summary

Gene Symbol

RDH5

Organism

Homo sapiens (human)

External Links

NCBI Gene

5959

PubChem

5959

Alliance of Genome Resources

HGNC:9940

JoGo

RDH5

TogoVar

RDH5

Annotation

Keyword

Disease variant
Endoplasmic reticulum
Glycoprotein
NAD
Oxidoreductase
Proteomics identification
Reference proteome
Steroid metabolism
Transmembrane helix
Vision

Proteins

Displaying 1 entry
UniProt	Protein Name
Q92781	11-cis retinol dehydrogenase 9-cis retinol dehydrogenase Short chain dehydrogenase/reductase family 9C member 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 7** of 7 in total

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2
GO Term	Evidence Code	PMID
steroid metabolic process	IBA
retinol metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

hormone metabolic process [inference]

retinol metabolic process

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

olefinic compound metabolic process [inference]

retinol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinol metabolic process

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinol metabolic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	IDA	11675386
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IDA	11675386
intracellular membrane-bounded organelle	IBA
cell body	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

cell body

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
NAD-retinol dehydrogenase activity	TAS
NAD-retinol dehydrogenase activity	IDA	11675386
NAD-retinol dehydrogenase activity	IBA
protein homodimerization activity	IDA	11675386
androsterone dehydrogenase activity	IDA	9931293

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

NAD-retinol dehydrogenase activity

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

11-cis-retinol dehydrogenase

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:11105	fundus albipunctatus	Alliance of Genome Resources
DOID:8499	night blindness	Alliance of Genome Resources

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026