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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

renin

Summary

Gene Symbol

REN

Organism

Homo sapiens (human)

External Links

NCBI Gene

5972

PubChem

5972

Alliance of Genome Resources

HGNC:9958

JoGo

REN

TogoVar

REN

Annotation

Keyword

3D-structure
Alternative splicing
Aspartyl protease
Cleavage on pair of basic residues
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Membrane
Proteomics identification
Reference proteome
Secreted
Signal
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P00797	Angiotensinogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
kidney development	IMP	16116425
mesonephros development	IEA
angiotensin maturation	TAS
angiotensin maturation	IDA	12045255
angiotensin maturation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

amyloid-beta metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

amyloid-beta metabolic process

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

primary metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

amyloid-beta metabolic process

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

cellular process [inference]

signal transduction [inference]

hormone-mediated signaling pathway

cellular developmental process [inference]

cell maturation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal system process involved in regulation of systemic arterial blood pressure [inference]

renin-angiotensin regulation of aldosterone production

behavior [inference]

feeding behavior [inference]

drinking behavior

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation

anatomical structure development [inference]

animal organ development [inference]

kidney development

mesonephros development

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

juxtaglomerular apparatus development

cellular developmental process [inference]

cell maturation

response to stimulus [inference]

response to stress [inference]

response to immobilization stress

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to xenobiotic stimulus [inference]

cellular response to xenobiotic stimulus

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to lipid [inference]

response to lipopolysaccharide

response to organophosphorus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to oxygen-containing compound [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of lipid localization [inference]

regulation of lipid transport [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

hormone-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of endocrine process [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

regulation of biological quality [inference]

regulation of blood pressure

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

regulation of hormone secretion [inference]

regulation of steroid hormone secretion [inference]

regulation of corticosteroid hormone secretion [inference]

regulation of mineralocorticoid secretion [inference]

regulation of aldosterone secretion [inference]

renin-angiotensin regulation of aldosterone production

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IDA	12045255 26322847
extracellular space	IBA
plasma membrane	TAS
apical part of cell	IDA	26322847

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

apical part of cell

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
aspartic-type endopeptidase activity	EXP	12045255 4289389 4322712 4330891 4360430
aspartic-type endopeptidase activity	IDA	12045255 20927107
aspartic-type endopeptidase activity	IBA
signaling receptor binding	IPI	12045255
insulin-like growth factor receptor binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

aspartic-type endopeptidase activity

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

aspartic-type endopeptidase activity

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity

binding [inference]

protein binding

signaling receptor binding

insulin-like growth factor receptor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

pregnancy-associated glycoprotein

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
aspartic-type endopeptidase activity
hydrolase activity
proteolysis

Displaying **all 4** entries
InterPro
Aspartic peptidase A1 family
Aspartic peptidase domain superfamily
Aspartic peptidase, active site
Peptidase family A1 domain

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060062	familial juvenile hyperuricemic nephropathy	Alliance of Genome Resources
DOID:10762	portal hypertension	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:10825	essential hypertension	Alliance of Genome Resources
DOID:10881	hand, foot and mouth disease	Alliance of Genome Resources

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026