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renin
Summary
- Gene Symbol
-
- REN
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Aspartyl protease
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Membrane
- Reference proteome
- Secreted
- Signal
- Zymogen
- Proteins
| UniProt | Protein Name |
|---|---|
| P00797 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| kidney development | ||
| mesonephros development | ||
| angiotensin maturation | ||
| angiotensin maturation | ||
| angiotensin maturation |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| extracellular space | ||
| plasma membrane | ||
| apical part of cell |
| GO Term | Evidence Code | PMID |
|---|---|---|
| aspartic-type endopeptidase activity | ||
| aspartic-type endopeptidase activity | ||
| aspartic-type endopeptidase activity | ||
| signaling receptor binding | ||
| insulin-like growth factor receptor binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- pregnancy-associated glycoprotein
- Functional Category
-
- E: Amino acid transport and metabolism
- K: Transcription
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| aspartic-type endopeptidase activity |
| hydrolase activity |
| proteolysis |
| InterPro |
|---|
| Aspartic peptidase A1 family |
| Aspartic peptidase domain superfamily |
| Aspartic peptidase, active site |
| Peptidase family A1 domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060062 | familial juvenile hyperuricemic nephropathy | |
| DOID:10762 | portal hypertension | |
| DOID:10763 | hypertension | |
| DOID:10825 | essential hypertension | |
| DOID:10881 | hand, foot and mouth disease |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 1509 | SGD:S000006075 | ||
| 1510 | SGD:S000006075 | ||
| 5972 | Xenbase:XB-GENE-480535 | ||
| 9476 | SGD:S000006075 | ||
| 13033 | SGD:S000006075 | ||
| 13034 | SGD:S000006075 | ||
| 16541 | SGD:S000006075 | ||
| 19701 | Xenbase:XB-GENE-480535 | MOUSE29212 | |
| 24715 | Xenbase:XB-GENE-480535 | RATNO06856 | |
| 25424 | SGD:S000006075 |
