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Guidelines

MIRAGE

apelin receptor

Summary

Gene Symbol

aplnr

Organism

Xenopus tropicalis (tropical clawed frog)

External Links

NCBI Gene

613084

PubChem

613084

Alliance of Genome Resources

Xenbase:XB-GENE-6456077

Annotation

Keyword

Angiogenesis
Cell membrane
Differentiation
G-protein coupled receptor
Gastrulation
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q4VA82	Angiotensin receptor-like 1 Angiotensin receptor-related protein G-protein coupled receptor APJ

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
angiogenesis	IEA
vasculogenesis	ISS
immune response	IBA
G protein-coupled receptor signaling pathway	ISS
G protein-coupled receptor signaling pathway	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

apelin receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cellular developmental process [inference]

cell differentiation

vasculogenesis

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

gastrulation

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

blood vessel development [inference]

coronary vasculature development

animal organ development [inference]

heart development

cellular developmental process [inference]

cell differentiation

vasculogenesis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of sequestering of calcium ion [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

apelin receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of sequestering of calcium ion [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	IEA
external side of plasma membrane	IBA
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor activity	IEA
G protein-coupled peptide receptor activity	ISS
C-C chemokine receptor activity	IBA
C-C chemokine binding	IBA
apelin receptor activity	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytokine binding [inference]

chemokine binding [inference]

C-C chemokine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity

apelin receptor activity

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

G protein-coupled receptor activity

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

G protein-coupled peptide receptor activity

apelin receptor activity

mechanoreceptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

apelin receptor A

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
C-C chemokine binding
C-C chemokine receptor activity
brain development
calcium-mediated signaling
cell chemotaxis
immune response
neurogenesis
positive regulation of cytosolic calcium ion concentration

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **1 - 10** of 21 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	185	WB:WBGene00012084
Caenorhabditis elegans	186	WB:WBGene00012084
Xenopus laevis	187	Xenbase:XB-GENE-6255483
Caenorhabditis elegans	623	WB:WBGene00012084
Caenorhabditis elegans	624	WB:WBGene00012084
Caenorhabditis elegans	11607	WB:WBGene00012084
Caenorhabditis elegans	11608	WB:WBGene00012084
Caenorhabditis elegans	11609	WB:WBGene00012084
Caenorhabditis elegans	12061	WB:WBGene00012084
Caenorhabditis elegans	12062	WB:WBGene00012084

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Last updated: April 7, 2025