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reticulon 1

Summary

Gene Symbol

RTN1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6252

PubChem

6252

Alliance of Genome Resources

HGNC:10467

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Golgi apparatus
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A8K3B9
Q16799	Neuroendocrine-specific protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
brain development	IBA
neuron differentiation	IEP	9560466
neuron differentiation	IBA
endoplasmic reticulum tubular network formation	IBA
negative regulation of amyloid-beta formation	IDA	15286784

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

endoplasmic reticulum organization [inference]

endoplasmic reticulum tubular network organization [inference]

endoplasmic reticulum tubular network formation

cellular component assembly [inference]

endoplasmic reticulum tubular network formation

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of amyloid-beta formation

regulation of amyloid-beta formation [inference]

negative regulation of amyloid-beta formation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of amyloid precursor protein catabolic process [inference]

regulation of amyloid-beta formation [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of amyloid precursor protein catabolic process [inference]

regulation of amyloid-beta formation [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of amyloid precursor protein catabolic process [inference]

regulation of amyloid-beta formation [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
Golgi membrane	IDA	12873973
endoplasmic reticulum	IDA	12873973
endoplasmic reticulum membrane	TAS	8833145
endoplasmic reticulum membrane	IDA	17684057
endoplasmic reticulum membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

Golgi membrane

nuclear body

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	12873973 15286784 17684057 17786215 25416956 25543119 25612671 32814053

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Reticulon

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Reticulon 1-4
Reticulon

Ortholog

Displaying entries **1 - 10** of 68 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6252	Xenbase:XB-GENE-1011333
Drosophila melanogaster	6253	FB:FBgn0053113
Drosophila melanogaster	10313	FB:FBgn0053113
Drosophila melanogaster	20168	FB:FBgn0053113
Drosophila melanogaster	57142	FB:FBgn0053113
Drosophila melanogaster	68585	FB:FBgn0053113
Mus musculus	104001	Xenbase:XB-GENE-1011333	MOUSE08896
Rattus norvegicus	116644		RATNO36329
Danio rerio	323706		DANRE06324
Danio rerio	327065		DANRE20025