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Guidelines

MIRAGE

reticulon 2

Summary

Gene Symbol

RTN2

Organism

Homo sapiens (human)

External Links

NCBI Gene

6253

PubChem

6253

Alliance of Genome Resources

HGNC:10468

Annotation

Keyword

Alternative initiation
Alternative splicing
Cell membrane
Cytoskeleton
Disease variant
Endoplasmic reticulum
Hereditary spastic paraplegia
Phosphoprotein
Reference proteome
Sarcoplasmic reticulum
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
O75298	Neuroendocrine-specific protein-like 1 Neuroendocrine-specific protein-like I
Q6GMT0
A8K7F2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
brain development	IBA
gene expression	IEA
neuron differentiation	IBA
regulation of glucose import	ISS
intracellular protein transmembrane transport	ISS

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport

protein transmembrane transport [inference]

intracellular protein transmembrane transport

transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

endoplasmic reticulum organization [inference]

endoplasmic reticulum tubular network organization [inference]

endoplasmic reticulum tubular network formation

cellular component assembly [inference]

endoplasmic reticulum tubular network formation

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport

protein transmembrane transport [inference]

intracellular protein transmembrane transport

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport

transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport

protein transmembrane transport [inference]

intracellular protein transmembrane transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport

protein transmembrane transport [inference]

intracellular protein transmembrane transport

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport

protein transmembrane transport [inference]

intracellular protein transmembrane transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport

protein transmembrane transport [inference]

intracellular protein transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of amyloid-beta formation

regulation of amyloid-beta formation [inference]

negative regulation of amyloid-beta formation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of amyloid precursor protein catabolic process [inference]

regulation of amyloid-beta formation [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of amyloid precursor protein catabolic process [inference]

regulation of amyloid-beta formation [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of amyloid precursor protein catabolic process [inference]

regulation of amyloid-beta formation [inference]

negative regulation of amyloid-beta formation

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of glucose transmembrane transport [inference]

regulation of glucose import

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amide metabolic process [inference]

negative regulation of amyloid-beta formation

negative regulation of protein metabolic process [inference]

negative regulation of amyloid precursor protein catabolic process [inference]

negative regulation of amyloid-beta formation

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

regulation of glucose transmembrane transport [inference]

regulation of glucose import

Displaying entry **11 - 11** of 11 in total

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GO Term	Evidence Code	PMID
neuron projection	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

sarcoplasmic reticulum membrane

bounding membrane of organelle [inference]

sarcoplasmic reticulum membrane

organelle subcompartment [inference]

endoplasmic reticulum subcompartment [inference]

terminal cisterna

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

postsynaptic specialization [inference]

postsynaptic density

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	15286784 22232211 25612671 33961781 35271311

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Reticulon

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Reticulon 1-4
Reticulon

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110765	hereditary spastic paraplegia 12	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 47 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	6252	FB:FBgn0053113
Xenopus tropicalis	6253	Xenbase:XB-GENE-941644
Drosophila melanogaster	10313	FB:FBgn0053113
Mus musculus	20167		MOUSE53287
Drosophila melanogaster	20168	FB:FBgn0053113
Drosophila melanogaster	57142	FB:FBgn0053113
Drosophila melanogaster	68585	FB:FBgn0053113
Drosophila melanogaster	104001	FB:FBgn0053113
Canis lupus familiaris	484444		CANLF00929
Takifugu rubripes	654269		TAKRU04324

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Last updated: December 8, 2025