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sodium voltage-gated channel alpha subunit 5
Summary
- Gene Symbol
-
- SCN5A
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Atrial fibrillation
- Brugada syndrome
- Calmodulin-binding
- Cardiomyopathy
- Cell junction
- Cell membrane
- Coiled coil
- Cytoplasm
- Disease variant
- Disulfide bond
- Glycoprotein
- Long QT syndrome
- Methylation
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Repeat
- Sodium channel
- Transmembrane helix
- Ubl conjugation
- Voltage-gated channel
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of heart rate | ||
| cardiac conduction system development | ||
| cardiac ventricle development | ||
| brainstem development | ||
| sodium ion transport |
GO Hierarchy
- membrane depolarization during AV node cell action potential
- membrane depolarization during SA node cell action potential
- membrane depolarization during Purkinje myocyte cell action potential
- membrane depolarization during bundle of His cell action potential
- membrane depolarization during atrial cardiac muscle cell action potential
biological process
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of biological quality [inference]
regulation of membrane potential [inference]
membrane depolarization
membrane depolarization during action potential
membrane depolarization during cardiac muscle cell action potential
| GO Term | Evidence Code | PMID |
|---|---|---|
| lateral plasma membrane | ||
| Z disc | ||
| T-tubule | ||
| sarcolemma | ||
| perinuclear region of cytoplasm |
| GO Term | Evidence Code | PMID |
|---|---|---|
| ubiquitin protein ligase binding | ||
| transmembrane transporter binding | ||
| nitric-oxide synthase binding | ||
| voltage-gated sodium channel activity involved in cardiac muscle cell action potential | ||
| voltage-gated sodium channel activity involved in cardiac muscle cell action potential |
GO Hierarchy
- voltage-gated sodium channel activity involved in AV node cell action potential
- voltage-gated sodium channel activity involved in bundle of His cell action potential
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential
- voltage-gated sodium channel activity involved in SA node cell action potential
- voltage-gated sodium channel activity involved in AV node cell action potential
- voltage-gated sodium channel activity involved in bundle of His cell action potential
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential
- voltage-gated sodium channel activity involved in SA node cell action potential
- voltage-gated sodium channel activity involved in AV node cell action potential
- voltage-gated sodium channel activity involved in bundle of His cell action potential
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential
- voltage-gated sodium channel activity involved in SA node cell action potential
- voltage-gated sodium channel activity involved in AV node cell action potential
- voltage-gated sodium channel activity involved in bundle of His cell action potential
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential
- voltage-gated sodium channel activity involved in SA node cell action potential
- voltage-gated sodium channel activity involved in AV node cell action potential
- voltage-gated sodium channel activity involved in bundle of His cell action potential
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential
- voltage-gated sodium channel activity involved in SA node cell action potential
- voltage-gated sodium channel activity involved in AV node cell action potential
- voltage-gated sodium channel activity involved in bundle of His cell action potential
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential
- voltage-gated sodium channel activity involved in SA node cell action potential
molecular function
transporter activity [inference]
transmembrane transporter activity [inference]
monoatomic ion transmembrane transporter activity [inference]
monoatomic ion channel activity [inference]
monoatomic cation channel activity [inference]
sodium channel activity [inference]
voltage-gated sodium channel activity
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
monoatomic cation transmembrane transporter activity [inference]
monoatomic cation channel activity [inference]
sodium channel activity [inference]
voltage-gated sodium channel activity
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
metal ion transmembrane transporter activity [inference]
sodium ion transmembrane transporter activity [inference]
sodium channel activity [inference]
voltage-gated sodium channel activity
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
inorganic molecular entity transmembrane transporter activity [inference]
inorganic cation transmembrane transporter activity [inference]
metal ion transmembrane transporter activity [inference]
sodium ion transmembrane transporter activity [inference]
sodium channel activity [inference]
voltage-gated sodium channel activity
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
passive transmembrane transporter activity [inference]
channel activity [inference]
monoatomic ion channel activity [inference]
monoatomic cation channel activity [inference]
sodium channel activity [inference]
voltage-gated sodium channel activity
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
salt transmembrane transporter activity [inference]
sodium ion transmembrane transporter activity [inference]
sodium channel activity [inference]
voltage-gated sodium channel activity
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Sodium channel protein
- Functional Category
-
- E: Amino acid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- P: Inorganic ion transport and metabolism
- T: Signal transduction mechanisms
| InterPro |
|---|
| Ion transport domain |
| Voltage-dependent channel domain superfamily |
| Voltage-gated cation channel calcium and sodium |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050650 | familial atrial fibrillation | |
| DOID:0110218 | Brugada syndrome 1 | |
| DOID:0110433 | dilated cardiomyopathy 1E | |
| DOID:0110646 | long QT syndrome 3 | |
| DOID:0111074 | progressive familial heart block type IA | |
| DOID:13884 | sick sinus syndrome | |
| DOID:2843 | long QT syndrome | |
| DOID:9007 | sudden infant death syndrome |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 773 | SGD:S000003449 | ||
| 774 | SGD:S000003449 | ||
| 775 | SGD:S000003449 | ||
| 776 | SGD:S000003449 | ||
| 777 | SGD:S000003449 | ||
| 778 | SGD:S000003449 | ||
| 779 | SGD:S000003449 | ||
| 6323 | SGD:S000003449 | ||
| 6326 | SGD:S000003449 | ||
| 6328 | SGD:S000003449 |
