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succinate dehydrogenase complex iron sulfur subunit B
Summary
- Gene Symbol
-
- SDHB
- Aliases
-
- iron-sulfur subunit of complex II
- succinate dehydrogenase [ubiquinone] iron-sulfur subunit
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 2Fe-2S
- 3D-structure
- 3Fe-4S
- 4Fe-4S
- Acetylation
- Disease variant
- Electron transport
- Host-virus interaction
- Mitochondrion inner membrane
- Oxidoreductase
- Primary mitochondrial disease
- Reference proteome
- Transit peptide
- Tricarboxylic acid cycle
- Proteins
| UniProt | Protein Name |
|---|---|
| P21912 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proton motive force-driven mitochondrial ATP synthesis |
|
|
| aerobic respiration | ||
| mitochondrial electron transport, succinate to ubiquinone |
|
|
| respiratory electron transport chain | ||
| tricarboxylic acid cycle |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
biosynthetic process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
aromatic compound biosynthetic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
heterocycle biosynthetic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
organophosphate metabolic process [inference]
organic cyclic compound metabolic process [inference]
organonitrogen compound metabolic process [inference]
organic substance biosynthetic process [inference]
cellular process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
aromatic compound biosynthetic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
heterocycle biosynthetic process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleoplasm |
| GO Term | Evidence Code | PMID |
|---|---|---|
| electron transfer activity | ||
| ubiquinone binding | ||
| 2 iron, 2 sulfur cluster binding | ||
| succinate dehydrogenase (ubiquinone) activity | ||
| 4 iron, 4 sulfur cluster binding |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050387 | nonpapillary renal cell carcinoma | |
| DOID:0050424 | familial adenomatous polyposis | |
| DOID:0050428 | nonepidermolytic palmoplantar keratoderma | |
| DOID:0050430 | multiple endocrine neoplasia type 2A | |
| DOID:0050486 | exanthem | |
| DOID:0050572 | cone-rod dystrophy | |
| DOID:0050657 | Bannayan-Riley-Ruvalcaba syndrome | |
| DOID:0050700 | cardiomyopathy | |
| DOID:0050771 | pheochromocytoma | |
| DOID:0050773 | paraganglioma |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0012062 | Bone cyst |
| HP:0012114 | Endometrial carcinoma |
| HP:0012222 | Arachnoid hemangiomatosis |
| HP:0012378 | Fatigue |
| HP:0012402 | Increased urine alpha-ketoglutarate concentration |
| HP:0012707 | Elevated brain lactate level by MRS |
| HP:0012733 | Macule |
| HP:0012740 | Papilloma |
| HP:0012817 | Noncompaction cardiomyopathy |
| HP:0100006 | Neoplasm of the central nervous system |
| Disease ID | Disease Name |
|---|---|
| ORPHA:276621 |
|
| OMIM:115310 |
|
| OMIM:606864 |
|
| ORPHA:201 |
|
| ORPHA:3208 |
|
| ORPHA:97286 |
|
| OMIM:606764 |
|
| ORPHA:44890 |
|
| ORPHA:29072 |
|
| OMIM:619224 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP000586
- Gene Name
- succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 113487958 | ATHCN19415 | ||
| 105824864 | PROCO07550 | ||
| 850685 | SGD:S000003964 | ||
| 109098216 | CYPCA118544 | ||
| 103725310 | NANGA17544 | ||
| 116454745 | CORMO10941 | ||
| 103257385 | CARSF23128 | ||
| 115617324 | STRHB16312 |
