GlyCosmos Portal

Annotation

Keyword

3D-structure
Alternative splicing
Autocatalytic cleavage
Calcium
Complement activation lectin pathway
Disulfide bond
EGF-like domain
Glycoprotein
Hydroxylation
Metal-binding
Reference proteome
Repeat
Secreted
Serine protease
Signal
Sushi

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8CHN8	Complement factor MASP-3 Complement-activating component of Ra-reactive factor Mannose-binding lectin-associated serine protease 1 Mannose-binding protein-associated serine protease Ra-reactive factor serine protease p100 Serine protease 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
proteolysis	IEA
complement activation, lectin pathway	IBA IEA ISO ISS
zymogen activation	IBA
innate immune response	IEA
negative regulation of complement activation	ISO

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

complement activation, lectin pathway

activation of immune response [inference]

complement activation

complement activation, lectin pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, lectin pathway

innate immune response

complement activation, lectin pathway

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

complement activation, lectin pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

complement activation, lectin pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, lectin pathway

innate immune response

complement activation, lectin pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

complement activation, lectin pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

complement activation, lectin pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, lectin pathway

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation

regulation of complement activation [inference]

negative regulation of complement activation

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

regulation of complement activation [inference]

negative regulation of complement activation

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, lectin pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, lectin pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, lectin pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

negative regulation of response to stimulus [inference]

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, lectin pathway

negative regulation of response to stimulus [inference]

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

regulation of complement activation [inference]

negative regulation of complement activation

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, lectin pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
nucleoplasm	IEA ISO
extracellular space	IBA IDA IEA ISO	12847554
cytosol	IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
calcium-dependent protein binding	IEA IPI ISO	10913141
identical protein binding	ISO
peptidase activity	ISO
calcium ion binding	IDA IEA ISO ISS	10913141
protein homodimerization activity	IEA IPI ISO	10913141 15060079

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

calcium-dependent protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

mannan-binding lectin serine protease 1

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
calcium ion binding
complement activation, lectin pathway
complement activation
hydrolase activity
immune system process
metal ion binding
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying entries **1 - 10** of 13 in total

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InterPro
CUB domain
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Peptidase S1A, complement C1r/C1S/mannan-binding
Serine proteases, trypsin domain
Serine proteases, trypsin family, serine active site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060575	3MC syndrome 1	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of **113** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Heterocephalus glaber	101716867	10181_0:000117
Mesocricetus auratus	101823015	10036_0:0020fa
Macaca fascicularis	101866962		MACFA25802
Melopsittacus undulatus	101872767		MELUD15699
Chrysemys picta bellii	101942804		CHRPI11561
Ictidomys tridecemlineatus	101969600	43179_0:003433	ICTTR07070
Microtus ochrogaster	101982626	79684_0:0004d0
Chinchilla lanigera	102025802	34839_0:0013a3	CHILA06023
Capra hircus	102171378		CAPHI12117
Haplochromis burtoni	102289885		HAPBU29455

GlyTouCan

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements