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MIRAGE
surfactant protein C

Summary
Gene Symbol
  • SFTPC
Aliases
  • BRICD6
  • BRICHOS domain containing 6
  • PSP-C
  • SMDP2
  • SP-C
Organism
Homo sapiens (human)
NCBI Gene
6440
HGNC
10802
KEGG Gene ID
hsa:6440
PubChem
6440
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Palmitate
  • Proteomics identification
  • Reference proteome
  • Surface film
  • Transmembrane helix
Proteins
Displaying all 3 entries
UniProt Protein Name
P11686
  • Pulmonary surfactant-associated protein C
  • Pulmonary surfactant-associated proteolipid SPL(Val)
  • SP5
A0A0S2Z4Q0
  • Pulmonary surfactant-associated protein C
  • Pulmonary surfactant-associated proteolipid SPL(Val)
E5RI64
  • Pulmonary surfactant-associated protein C
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 7 in total
GO Term Evidence Code PMID
extracellular region
extracellular space
endoplasmic reticulum membrane
lamellar body
clathrin-coated endocytic vesicle
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
Pulmonary surfactant-associated protein C
Functional Category
  • O: Posttranslational modification, protein turnover, chaperones
  • P: Inorganic ion transport and metabolism
  • T: Signal transduction mechanisms
Displaying 1 entry
Gene Ontology
respiratory gaseous exchange by respiratory system
Displaying all 3 entries
InterPro
BRICHOS domain
Pulmonary surfactant-associated protein C
Surfactant protein C, N-terminal propeptide
Human Protein Atlas
ENSG00000168484

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas
KEGG BRITE Database
Orthology
K26068
Name
pulmonary surfactant-associated protein C
References
Disease
Disease Ontology
Displaying all 9 entries
DO ID Disease Name Source
DOID:11394 adult respiratory distress syndrome
DOID:12120 pulmonary alveolar proteinosis
DOID:1273 respiratory syncytial virus infectious disease
DOID:2841 asthma
DOID:3082 interstitial lung disease
DOID:3083 chronic obstructive pulmonary disease
DOID:3770 pulmonary fibrosis
DOID:850 lung disease
DOID:9675 pulmonary emphysema
The Human Phenotype Ontology
Displaying entries 1 - 10 of 42 in total
HPO ID HPO Term
HP:0000006 Autosomal dominant inheritance
HP:0000765 Abnormal thorax morphology
HP:0000961 Cyanosis
HP:0001063 Acrocyanosis
HP:0001217 Clubbing
HP:0001263 Global developmental delay
HP:0001394 Cirrhosis
HP:0001508 Failure to thrive
HP:0001622 Premature birth
HP:0001649 Tachycardia
Displaying all 4 entries
Disease ID Disease Name
OMIM:610913
  • surfactant metabolism dysfunction, pulmonary, 2
ORPHA:2032
  • interstitial lung disease 2
ORPHA:70587
  • respiratory distress syndrome in premature infants
OMIM:178500
  • interstitial lung disease 2
PubChem Disease
GHR Health Conditions
MedGen Diseases
OMIM Phenotypes
KEGG Diseases
Gene-Disease-Co-Occurrences-in-Literature (PubChem)
Ortholog
Displaying entries 1 - 10 of 51 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
6440 Xenbase:XB-GENE-852771
20389 MOUSE13007
50683 RATNO10369
282071 BOVIN34706
443034 SHEEP08934
477385 CANLF10015
707696 MACMU43312
733580 PIGXX06370
100030529 MONDO03348
100087361 ORNAN22113
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025