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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
transferrin receptor
Summary
- Gene Symbol
-
- Tfrc
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Cell membrane
- Disulfide bond
- Endocytosis
- Glycoprotein
- Palmitate
- Phosphoprotein
- Receptor
- Reference proteome
- Signal-anchor
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| Q99376 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| iron ion transport | ||
| intracellular iron ion homeostasis | ||
| transferrin transport | ||
| regulation of postsynaptic membrane neurotransmitter receptor levels | ||
| positive regulation of protein localization to nucleus |
GO Hierarchy
biological process
homeostatic process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
positive regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of cellular component organization [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| recycling endosome | ||
| external side of plasma membrane | ||
| HFE-transferrin receptor complex | ||
| cytoplasmic vesicle | ||
| membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| protein-containing complex binding | ||
| transferrin receptor activity | ||
| double-stranded RNA binding | ||
| protein-folding chaperone binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- Transferrin receptor-like, dimerisation domain
- Functional Category
-
- H: Coenzyme transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
| Gene Ontology |
|---|
| intracellular iron ion homeostasis |
| receptor internalization |
| transferrin receptor activity |
| transferrin transport |
Alliance of Genome Resources
- Expression
| Location | References |
|---|---|
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080208 | metabolic dysfunction-associated steatotic liver disease | |
| DOID:0111948 | immunodeficiency 46 | |
| DOID:10283 | prostate cancer | |
| DOID:11758 | iron deficiency anemia | |
| DOID:1612 | breast cancer | |
| DOID:1724 | duodenal ulcer | |
| DOID:2394 | ovarian cancer | |
| DOID:2671 | transitional cell carcinoma | |
| DOID:3459 | breast carcinoma | |
| DOID:3702 | cervical adenocarcinoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 7037 | HGNC:11763 | HUMAN74189 | ||
| 22042 | 10090_1:004979 | MGI:98822 | MOUSE19576 | |
| 397062 | PIGXX05454 | |||
| 403703 | CANLF13393 | |||
| 460956 | PANTR33004 | |||
| 493880 | FELCA23549 | |||
| 494477 | ZFIN:ZDB-GENE-041220-1 | DANRE28382 | ||
| 494478 | ZFIN:ZDB-GENE-041220-2 | |||
| 504698 | BOVIN14691 | |||
| 711568 | MACMU30004 |
