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MIRAGE

cytochrome P450 family 3 subfamily A member 43

Summary

Gene Symbol

CYP3A43

Organism

Homo sapiens (human)

External Links

NCBI Gene

64816

PubChem

64816

Alliance of Genome Resources

HGNC:17450

Annotation

Keyword

Alternative splicing
Heme
Membrane
Microsome
Monooxygenase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9HB55

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
steroid metabolic process	IBA
oxidative demethylation	IBA
cytochrome metabolic process	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

cytochrome metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

protein metabolic process [inference]

cytochrome metabolic process

demethylation [inference]

oxidative demethylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

cytochrome metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

cytochrome metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
monooxygenase activity	ISS
monooxygenase activity	TAS
iron ion binding	IEA
heme binding	IEA
testosterone 6-beta-hydroxylase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity

steroid hydroxylase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

aromatase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

aromatase activity

estrogen 16-alpha-hydroxylase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytochrome p450

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity

Displaying **all 4** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

Ortholog

Displaying entries **11 - 20** of 70 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Monodelphis domestica	100010820		MONDO30917
Ornithorhynchus anatinus	100082190		ORNAN15461
Ornithorhynchus anatinus	100082218		ORNAN15495
Ornithorhynchus anatinus	100082250		ORNAN15495
Ornithorhynchus anatinus	100082275		ORNAN15553
Ornithorhynchus anatinus	100091970		ORNAN15553
Taeniopygia guttata	100226034		TAEGU05012
Pongo abelii	100437391		PONAB33960
Anolis carolinensis	100555955		ANOCA12612
Loxodonta africana	100677295		LOXAF07608

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025