GlyCosmos Portal

sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1

Summary

Gene Symbol

Svep1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

64817

PubChem

64817

Alliance of Genome Resources

MGI:1928849

Annotation

Keyword

Alternative splicing
Calcium
Cell adhesion
Cytoplasm
Disulfide bond
EGF-like domain
Glycoprotein
Membrane
Nucleus
Reference proteome
Repeat
Secreted
Signal
Sushi

Proteins

Displaying 1 entry
UniProt	Protein Name
A2AVA0	Polydom

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
lymph vessel development	IMP	28179432
lymph circulation	IMP	28179430
cell-matrix adhesion	IEA
epidermis development	ISO	27892606
epidermis development	IMP	27892606

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

cell-cell adhesion [inference]

epithelial cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

Tie signaling pathway

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

cell-cell junction organization [inference]

tight junction organization

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

lymph circulation

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

developmental process [inference]

anatomical structure morphogenesis [inference]

lymph vessel morphogenesis

anatomical structure development [inference]

lymph vessel development

tissue development [inference]

epidermis development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

Tie signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

regulation of cell activation [inference]

regulation of platelet activation [inference]

positive regulation of platelet activation

positive regulation of cell activation [inference]

positive regulation of platelet activation

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

regulation of cell activation [inference]

regulation of platelet activation [inference]

positive regulation of platelet activation

positive regulation of cell activation [inference]

positive regulation of platelet activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

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GO Term	Evidence Code	PMID
extracellular region	ISS	11062057
extracellular region	IDA	22654117
extracellular space	IDA	28179430
extracellular space	HDA	24006456
nucleus	ISO	27892606

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
chromatin binding	IDA	15522233
integrin binding	ISO
integrin binding	IMP	28179430
calcium ion binding	IEA
protein binding	IPI	28179430 36792666

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

integrin binding involved in cell-matrix adhesion

cell adhesion molecule binding [inference]

integrin binding

integrin binding involved in cell-matrix adhesion

cell adhesion mediator activity [inference]

cell-matrix adhesion mediator activity [inference]

integrin binding involved in cell-matrix adhesion

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

chromatin binding

integrin binding

integrin binding involved in cell-matrix adhesion

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

uncharacterized protein, isoform A

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 10** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Growth factor receptor cysteine-rich domain superfamily
HYR domain
Sushi/SCR/CCP domain
Sushi/SCR/CCP superfamily
Tyrosine-protein kinase ephrin type A/B receptor-like

Ortholog

Displaying entries **1 - 10** of 91 in total

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Species	Gene ID	Alliance of Genome Resources
Drosophila melanogaster	722	FB:FBgn0001083
Caenorhabditis elegans	1378	WB:WBGene00002976
Caenorhabditis elegans	1379	WB:WBGene00002976
Caenorhabditis elegans	6401	WB:WBGene00002976
Caenorhabditis elegans	6403	WB:WBGene00002976
Caenorhabditis elegans	12269	WB:WBGene00002976
Caenorhabditis elegans	22789	WB:WBGene00002976
Xenopus tropicalis	32162	Xenbase:XB-GENE-5996067
Rattus norvegicus	33983	RGD:1588987
Xenopus tropicalis	64817	Xenbase:XB-GENE-5996067

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements