ST3 beta-galactoside alpha-2,3-sialyltransferase 4

Summary
Gene Symbol
  • ST3GAL4
Aliases
  • FLJ11867
  • SAT3
  • ST3Gal IV
  • STZ
Organism
Homo sapiens (human)
External Links
NCBI Gene
6484
GGDB ID
HGNC
10864
mRNA
map
  • 11q23-q24
Protein
OMIM
KEGG Gene ID
hsa:6484
PubChem
6484
Alliance of Genome Resources
Annotation
Keyword
  • Alternative splicing
  • Disulfide bond
  • Glycoprotein
  • Glycosyltransferase
  • Golgi apparatus
  • Lipid metabolism
  • Proteomics identification
  • Reference proteome
  • Secreted
  • Signal
  • Signal-anchor
  • Transferase
  • Transmembrane helix
Proteins
Displaying all 4 entries
UniProt Protein Name
Q6IBE6
Q11206
  • Alpha 2,3-sialyltransferase IV
  • Gal-NAc6S
  • Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
  • Gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase
  • N-acetyllactosaminide alpha-2,3-sialyltransferase
  • SAT-3
  • ST-4
  • ST3Gal IV
  • ST3GalA.2
  • STZ
  • Sialyltransferase 4C
A0A7P0RGI5
A0A7I2V5F3
Gene Ontology (GO)
GO Hierarchy
Human Protein Atlas
ENSG00000110080

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

GlycoGene Database (GGDB)
GGDB ID
gg051
Gene Symbol
  • ST3GAL4
Reactions
Displaying all 2 entries
Donor Acceptor Product Reference
CMP-Neu5Ac
G00031MO
G65562ZE
CMP-Neu5Ac
G58896AZ
Displaying all 5 entries
Donor Acceptor Product Reference
CMP-Neu5Ac
G00055MO
CMP-Neu5Ac
G58896AZ
CMP-Neu5Ac
G84224TW
G91237TK
CMP-Neu5Ac
G00031MO
G65562ZE
CMP-Neu5Ac
G64973KT
G11457RF
Displaying all 4 entries
Donor Acceptor Product Reference
CMP-Neu5Ac
G72002FC
CMP-Neu5Ac
G00056MO
CMP-Neu5Ac
G26123AX
CMP-Neu5Ac
G00049MO
Orthologous Gene
Displaying all 2 entries
Species Protein mRNA
Rattus norvegicus NP_976082 NM_203337
Mus musculus NP_033204 NM_009178
KEGG BRITE Database
Orthology
K03494
Name
beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4C) [EC:2.4.3.2 2.4.3.4 2.4.3.6]
References
Reactions
Displaying 1 entry
KEGG Reaction Enzyme Acceptor Product
R06153
Disease
Disease Ontology
Displaying entries 1 - 10 of 179 in total
DO ID Disease Name Source
DOID:0014667 disease of metabolism
DOID:0050387 nonpapillary renal cell carcinoma
DOID:0050463 campomelic dysplasia
DOID:0050700 cardiomyopathy
DOID:0050782 Zollinger-Ellison syndrome
DOID:0050865 tongue squamous cell carcinoma
DOID:0060262 gallbladder disease
DOID:0060307 autosomal dominant intellectual developmental disorder
DOID:0060672 Grn-related frontotemporal lobar degeneration with Tdp43 inclusions
DOID:0070034 autosomal dominant intellectual developmental disorder 4
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP001000
Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 4

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024